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| ID | Type | Description | Link |
|---|---|---|---|
| BioReb #10-227 | Other Identifier | University of Saskatchewan |
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Exposure to allergens changes the way the airway responds to some stimuli (methacholine). The investigators will look at whether or not exposure to allergens changes the way the airway responds to a different stimuli (mannitol) and compare that with the known stimuli (methacholine).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Mannitol | Experimental | This arm will assess the allergen induced change in airway responsiveness to mannitol bronchoprovocation. |
|
| Methacholine Chloride | Active Comparator | This arm will assess the allergen induced change in airway responsiveness to methacholine bronchoprovocation. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Mannitol | Drug | Indirect bronchoprovocation agent being compared to direct bronchoprovocation agent (methacholine) |
|
| Measure | Description | Time Frame |
|---|---|---|
| Change from baseline in airway responsiveness three hours after allergen exposure | Change from Baseline at 3 hours |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Donald W Cockcroft, MD | University of Saskatchewan | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Saskatchewan | Saskatoon | Saskatchewan | S7N 0W8 | Canada |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 23987192 | Derived | Amakye DO, Davis BE, Martin AL, Peters GE, Cockcroft DW. Refractoriness to inhaled mannitol 3 hours after allergen challenge. Ann Allergy Asthma Immunol. 2013 Sep;111(3):182-4. doi: 10.1016/j.anai.2013.06.011. Epub 2013 Jul 12. |
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| ID | Term |
|---|---|
| D001249 | Asthma |
| D006967 | Hypersensitivity |
| ID | Term |
|---|---|
| D001982 | Bronchial Diseases |
| D012140 | Respiratory Tract Diseases |
| D008173 | Lung Diseases, Obstructive |
| D008171 | Lung Diseases |
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| ID | Term |
|---|---|
| D008353 | Mannitol |
| D016210 | Methacholine Chloride |
| ID | Term |
|---|---|
| D013402 | Sugar Alcohols |
| D000438 | Alcohols |
| D009930 | Organic Chemicals |
| D002241 | Carbohydrates |
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| Methacholine Chloride | Drug | Direct bronchoprovocation agent being compared to indirect bronchoprovocation agent (mannitol) |
|
|
| D012130 |
| Respiratory Hypersensitivity |
| D006969 | Hypersensitivity, Immediate |
| D007154 | Immune System Diseases |
| D008688 |
| Methacholine Compounds |
| D050337 | Trimethyl Ammonium Compounds |
| D000644 | Quaternary Ammonium Compounds |
| D000588 | Amines |
| D009861 | Onium Compounds |