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The study will compare the airway responses to two bronchoconstricting agents, mannitol and methacholine.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Methacholine (Provocholine) with deep inhalation | Experimental |
| |
| Mannitol (Aridol) | Experimental |
| |
| Methacholine (Provocholine) tidal breathing | Active Comparator |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Methacholine (Provocholine) | Drug | two minutes of aerosol inhalation of concentrations of methacholine ranging from 0.03 - 256mg/mL |
|
| Measure | Description | Time Frame |
|---|---|---|
| Airway responsiveness (PC20) to methacholine delivered over two minutes of tidal breathing | The two minute tidal breathing PC20 with be captured once at visit 1. | Visit 1 (Day 1) |
| airway responsiveness (PD15) to inhaled mannitol | The PD15 to mannitol will be captured once at either visit 2 or visit 3. | Visit 2 = up to 13 days |
| Airway responsiveness (PC20) to deep inhalation methacholine | The PC20 to methacholine (deep inhalation) will be captured once at either visit 2 or visit 3. | Visit 3 = up to 14 days |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Saskatchewan | Saskatoon | Saskatchewan | S7N0W8 | Canada |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 24702886 | Derived | Davis BE, Stewart SL, Martin AL, Cockcroft DW. Low levels of fractional exhaled nitric oxide and deep inhalation bronchoprotection are associated with mannitol non-responsiveness in asthma. Respir Med. 2014 Jun;108(6):859-64. doi: 10.1016/j.rmed.2014.03.005. Epub 2014 Mar 20. |
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| ID | Term |
|---|---|
| D001249 | Asthma |
| ID | Term |
|---|---|
| D001982 | Bronchial Diseases |
| D012140 | Respiratory Tract Diseases |
| D008173 | Lung Diseases, Obstructive |
| D008171 | Lung Diseases |
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| ID | Term |
|---|---|
| D016210 | Methacholine Chloride |
| D008353 | Mannitol |
| ID | Term |
|---|---|
| D008688 | Methacholine Compounds |
| D050337 | Trimethyl Ammonium Compounds |
| D000644 | Quaternary Ammonium Compounds |
| D000588 | Amines |
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| Mannitol (Aridol) | Drug | single deep inhalation of dry powder per dose doses range from 0mg - 160mg (cumulative dose range 0mg-635mg). |
|
| Methacholine (Provocholine) | Drug | two minutes of aerosol inhalation of concentrations of methacholine ranging from 0.03 - 256mg/mL every 20 seconds a deep inhalation is performed |
|
| D012130 |
| Respiratory Hypersensitivity |
| D006969 | Hypersensitivity, Immediate |
| D006967 | Hypersensitivity |
| D007154 | Immune System Diseases |
| D009930 | Organic Chemicals |
| D009861 | Onium Compounds |
| D013402 | Sugar Alcohols |
| D000438 | Alcohols |
| D002241 | Carbohydrates |