A Phase I Study to Evaluate the Safety, Tolerability, Pharmacokinetics (PK), Pharmacodynamics (PD), Food Effect of AMG 357 in Healthy Subjects

Study to evaluate the safety, tolerability, PK, PD, and food effect of AMG 357 in healthy subjects

Inclusion Criteria:

• Healthy Adult subjects between 25 and 55 years old
• Body mass index (BMI) between 18 and 32 kg/m2
• Normal or clinically acceptable physical examination, clinical laboratory values, and ECG
• Additional inclusion criteria apply

Exclusion Criteria:

• Any history or evidence of a clinically significant disorder, condition or disease that would pose a risk to subject safety.
• Additional exclusion criteria apply