Single Ascending Dose Study of AMG 570 in Healthy Subjects

A Randomized, Double Blind Placebo Controlled, First in Human Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Single Ascending Subcutaneous Doses of AMG 570 in Healthy Subjects

The purpose of this study is to obtain initial information on the safety and tolerability (effects good or bad), pharmacokinetics (what the body does to the drug), and pharmacodynamics (what the drug does to the body) of a single dose of AMG 570.

Inclusion Criteria:

• Healthy as determined by the investigator
• Normal or clinically acceptable electrocardiogram (ECG)
• Female subjects must be of documented non-reproductive potential
• Subjects must be current for all vaccinations
• Other inclusion criteria may apply

Exclusion Criteria:

• Current or chronic history of liver disease
• History of active infections
• History of significant respiratory disorder
• Evidence of renal disease
• Other exclusion criteria may apply