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The present study will explore the effectiveness of a computer based neurobehavioral intervention in alleviating symptoms and improving emotion regulation in individuals with PTSD. It will increase understanding of psychopathology at a neural-circuit level and aid development of new non-pharmacological treatment for PTSD. The study is managed by the Etkin Lab at Stanford University in California, but participants from the entire US are welcome to participate as the study is delivered online.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Engaging in Computerized tasks | Active Comparator | Participants will log into a personalized website and engage in computerized tasks online. |
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| Neurobehavioral computerized tasks | Experimental | Participants will log into a personalized website and engage in computerized tasks online. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Computerized Neurobehavioral Intervention | Behavioral | Targeted, computerized interventions completed from the participants' own home on a computer. |
|
| Measure | Description | Time Frame |
|---|---|---|
| WebNeuro Computerized Cognitive and Affective Assessment Battery | Age and gender-normed Z scores for the following measures: Sustained attention accuracy, Sustained attention lapses, Sustained attention false alarms, Working memory capacity, Visual scanning speed, Inhibition executive control, Processing speed, Maze completion executive control accuracy, Maze completion executive control speed, Immediate verbal memory, Delayed verbal memory, Inhibitory motor control accuracy, Inhibitory motor control lapses, Facial affect identification accuracy (happy, fearful, angry, sad, and disgusted), Facial affect identification speed (happy, angry, fearful, sad, or disgusted), Facial affect identity recognition accuracy (happy, angry, sad, fearful, or disgusted), Facial affect identity recognition speed (happy, sad, angry, fearful, or disgusted), Emotional conflict reaction time slowdown, Regulation of emotional conflict reaction time slowdown | Baseline and 3-month |
| Measure | Description | Time Frame |
|---|---|---|
| Clinician-assessed PTSD symptoms | Total and symptom sub scale scores from the Clinician-Administered PTSD Scale for DSM-IV (CAPS) | Baseline and 3-month |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Stanford University, Department of Psychiatry and Behavioral Sciences | Stanford | California | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 31125916 | Derived | Fonzo GA, Fine NB, Wright RN, Achituv M, Zaiko YV, Merin O, Shalev AY, Etkin A. Internet-delivered computerized cognitive & affective remediation training for the treatment of acute and chronic posttraumatic stress disorder: Two randomized clinical trials. J Psychiatr Res. 2019 Aug;115:82-89. doi: 10.1016/j.jpsychires.2019.05.007. Epub 2019 May 8. |
| Label | URL |
|---|---|
| Related Info | View source |
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| ID | Term |
|---|---|
| D001008 | Anxiety Disorders |
| D003863 | Depression |
| ID | Term |
|---|---|
| D001523 | Mental Disorders |
| D001526 | Behavioral Symptoms |
| D001519 | Behavior |
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