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The research proposes to use an innovative solution to shape brain circuits that support executive function and emotion reactivity -using targeted neurobehavioral intervention.
Participants will be recruited locally in the San Francisco Bay area with certain symptoms of anxiety and depression. They will complete a clinical assessment and then take part in a cognitive-emotion training delivered online.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Computerized intervention | Experimental | Participants will be asked to visit a customized website and engage in computerized exercises. Cognitive and emotion training games. |
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| Control | Sham Comparator | Participants will be asked to visit a customized website and engage in computerized games. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Computerized neurobehavioral intervention | Behavioral | Participants will complete the intervention by logging into a secure online website and complete computerized neurobehavioral tasks. Tasks will train the following - cognitive control, working memory and task shifting with two different tasks that engage these skills and positivity biases. |
| Measure | Description | Time Frame |
|---|---|---|
| Completion | We anticipate that participants will complete at least 30-days of the intervention. | 60 days |
| Proximal outcomes | We anticipate that proximal measures of symptoms will show improvement following the training in terms of emotional reactivity, implicit emotion regulation, negative emotional memory bias, attentional bias for threat, executive functions behaviorally and N-back during fMRI as well as resting-state fMRI connectivity. | 60 days |
| Distal outcomes | We anticipate that anxiety and depression symptoms, explicit emotion regulation capacities and quality of life reported on self-report measures will show improvement. | 5 months |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| VA Palo Alto Health Care System (VAPAHCS) | Palo Alto | California | 94304 | United States | ||
| Stanford University Department of Pscyhiatry and Behavioral Sciences |
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|
| Stanford |
| California |
| 94304 |
| United States |
| ID | Term |
|---|---|
| D003863 | Depression |
| D001008 | Anxiety Disorders |
| D000080103 | Emotional Regulation |
| ID | Term |
|---|---|
| D001526 | Behavioral Symptoms |
| D001519 | Behavior |
| D001523 | Mental Disorders |
| D000068356 | Self-Control |
| D012919 | Social Behavior |
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