Glypican4 and CTRP5 in Metabolic Syndrome and the Effect of Exercise on These Adipokines

Effects of Exercise on Glypican4,CTRP3,5 and RBP4 Levels and Circulating Levels of These Adipokines in the Subjects With or Without Metabolic Syndrome

Glypican4, CTRP3, CTRP5 are emerging novel adipokines mediating obesity and inflammation related disorders. RBP4 and adiponectin are well known important adipokines. Therefore, we examine the circulating levels of theses adipokines in the subjects with or without metabolic syndrome. Furthermore, we tried to clarify the effect of exercise on the circulating these adipokines.

Inclusion Criteria:

• Women between 30 and 60 years of age who had a body mass index (BMI) more than 25 kg/m2
• The subjects of metabolic syndrome and age, gender matched non metabolic syndrome among the participants of Korean SO Study (KSOS) study, which is an ongoing epidemiologic study supported by the Korea Science and Engineering Foundation

Exclusion Criteria:

• participants had a history of cardiovascular disease
• any type of diabetes
• stage 2 hypertension
• malignant disease, severe renal, or hepatic disease
• Subjects taking medications that might affect body weight or body composition