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Glypican4, CTRP3, CTRP5 are emerging novel adipokines mediating obesity and inflammation related disorders. RBP4 and adiponectin are well known important adipokines. Therefore, we examine the circulating levels of theses adipokines in the subjects with or without metabolic syndrome. Furthermore, we tried to clarify the effect of exercise on the circulating these adipokines.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Exercise | Other | obese women who are volunteers for the 3 months exercise programs |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| 3months Exercise | Behavioral | training session consisting of a brief warm-up, followed by an approximately 45-min session of aerobic exercise at an intensity of 60-75% of the age-predicted maximum heart rate (approximately 300 kcal/day) and a 20-min muscle strength train- ing programme (approximately 100 kcal/day), followed by a brief cool-down period. |
| Measure | Description | Time Frame |
|---|---|---|
| The changes of circulating glypican4 levels after 3 months exercise | baseline and 12weeks | |
| The changes of circulating CTRP3 levels after 3 months exercise | baseline and 12weeks | |
| The changes of circulating CTRP5 levels after 3 months exercise | baseline and 12weeks | |
| The changes of circulating RBP4 levels after 3 months exercise | baseline and 12weeks | |
| The changes of circulating adiponectin levels after 3 months exercise | baseline and 12weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Circulating glypican4 levels in the subjects with or without metabolic syndrome | baseline | |
| Circulating CTRP3 levels in the subjects with or without metabolic syndrome | baseline | |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Korea University Guro Hospital | Seoul | South Korea |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 23780948 | Derived | Choi HY, Park JW, Lee N, Hwang SY, Cho GJ, Hong HC, Yoo HJ, Hwang TG, Kim SM, Baik SH, Park KS, Youn BS, Choi KM. Effects of a combined aerobic and resistance exercise program on C1q/TNF-related protein-3 (CTRP-3) and CTRP-5 levels. Diabetes Care. 2013 Oct;36(10):3321-7. doi: 10.2337/dc13-0178. Epub 2013 Jun 18. | |
| 23633195 | Derived |
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| ID | Term |
|---|---|
| D024821 | Metabolic Syndrome |
| D009765 | Obesity |
| ID | Term |
|---|---|
| D007333 | Insulin Resistance |
| D006946 | Hyperinsulinism |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
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| ID | Term |
|---|---|
| D015444 | Exercise |
| ID | Term |
|---|---|
| D009043 | Motor Activity |
| D009068 | Movement |
| D009142 | Musculoskeletal Physiological Phenomena |
| D055687 | Musculoskeletal and Neural Physiological Phenomena |
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|
| Circulating CTRP5 levels in the subjects with or without metabolic syndrome |
| baseline |
| Circulating RBP4 levels in the subjects with or without metabolic syndrome | baseline |
| Circulating adiponectin levels in the subjects with or without metabolic syndrome | baseline |
| Yoo HJ, Hwang SY, Cho GJ, Hong HC, Choi HY, Hwang TG, Kim SM, Bluher M, Youn BS, Baik SH, Choi KM. Association of glypican-4 with body fat distribution, insulin resistance, and nonalcoholic fatty liver disease. J Clin Endocrinol Metab. 2013 Jul;98(7):2897-901. doi: 10.1210/jc.2012-4297. Epub 2013 Apr 30. |
| D009750 |
| Nutritional and Metabolic Diseases |
| D050177 | Overweight |
| D044343 | Overnutrition |
| D009748 | Nutrition Disorders |
| D001835 | Body Weight |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |