The Effect of Acute and Chronic Exercise at the Metabolic Syndrome and Markers of Inflammation in Obese Subjects

The Effect of Acute and Chronic Exercise at the Metabolic Syndrome and Markers of Inflammation in Obese Subjects

The human adipose and muscle -tissue produce and release a number of bioactive proteins which contributes to the chronic low grade of inflammatory status which is associated with obesity and plays an important role in the pathogenesis of type 2 diabetes and cardiovascular diseases.

Study 1: Our aim is to investigate if exercise has independent and additive effects in combination with diet-induced weight loss on circulating levels of inflammatory markers and mRNA levels in subcutaneous adipose tissue (SAT) and skeletal muscle tissue (SM.

Study 2: Our aim is to investigate whether gender and weight status plays a role in the metabolic response during two hours of acute exercise

Inclusion Criteria:

• Age 18-45 years,
• obese (30 kg/m2 < BMI < 40 kg/m2) physically inactive (<30 minutes pr. day)
• and weight stabile for at least three months (± 2 kg of current body weight)

Exclusion Criteria:

• cardiovascular disease,
• type 2 diabetes, pregnancy or orthopaedic difficulties causing inability to undertake an exercise program