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The aim of our study was to evaluate the effect of different temperature regimens of cardiopulmonary bypass on systemic oxygen transport and cerebral oxygenation during surgical correction of acquired heart diseases.
Our aim was to evaluate the effect of hypothermic and normothermic regimens of cardiopulmonary bypass on systemic oxygen transport and cerebral oxygenation during valve surgery
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| normothermic CPB | Active Comparator | cardiopulmonary bypass with maintenance of normal body temperature |
|
| hypothermic CPB | Active Comparator | cardiopulmonary bypass using mild hypothermia |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| hypothermic CPB | Device | maintenance of mild hypothermia during cardiopulmonary bypass |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Cerebral oxygen saturation | measurement of cerebral oxygen saturation during cardiopulmonary bypass and 24 hrs postoperatively | perioperatively |
| Measure | Description | Time Frame |
|---|---|---|
| time until "fit for ICU discharge" fulfillment | measurement of time to fulfillment of the "fit for discharge" criteria | 5 days postoperatively |
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Inclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Mikhail Y Kirov, MD, PhD | Northern State Medical Univercity | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Dep. of Anesthesiology, Northern SMU | Arkhangelsk | 163000 | Russia |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 23407696 | Derived | Lenkin AI, Zaharov VI, Lenkin PI, Smetkin AA, Bjertnaes LJ, Kirov MY. Normothermic cardiopulmonary bypass increases cerebral tissue oxygenation during combined valve surgery: a single-centre, randomized trial. Interact Cardiovasc Thorac Surg. 2013 May;16(5):595-601. doi: 10.1093/icvts/ivt016. Epub 2013 Feb 13. |
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| ID | Term |
|---|---|
| D006349 | Heart Valve Diseases |
| D007035 | Hypothermia |
| ID | Term |
|---|---|
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
| D001832 | Body Temperature Changes |
| D012816 | Signs and Symptoms |
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| normothermic CPB |
| Device |
maintenance of normal body temperature during cardiopulmonary bypass |
|
| D013568 |
| Pathological Conditions, Signs and Symptoms |