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Subjects with wet AMD, dry AMD, and age-matched controls will undergo routine occular measurements, will provide a blood and cheek cell sample, and will have macular pigment optical density (MPOD) measured to determine if there is an association between genetics, MPOD and the risk of progression to wet AMD.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| choroidal neovascular (CNV) AMD subjects | Subjects diagnosed with CNV (AREDS Grade 4b) | ||
| dry AMD subjects | Subjects diagnosed with dry AMD (AREDS Grade 3) | ||
| age-matched controls | Subjects without AMD (AREDS Grade 1) |
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| Measure | Description | Time Frame |
|---|---|---|
| Association between a genetic variant in the CFH gene and risk of progression to CNV | DNA extracted from blood and buccal cells collected from subjects with either CNV, dry AMD, and age-matched controls will be analyzed to investigate a genetic variant in the CFH gene and its association with risk of progression to CNV | Baseline |
| Measure | Description | Time Frame |
|---|---|---|
| Genetic correlation between MPOD and risk of progression to CNV | DNA extracted from blood and buccal cells collected from subjects with either CNV, dry AMD, and age-matched controls will be analyzed to investigate the correlation between genetics, MPOD, and risk of progression to CNV | baseline |
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Inclusion Criteria:
Exclusion Criteria:
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Non-Hispanic Caucasian subjects 60 years of age and older diagnosed with either CNV or dry AMD and a cohort of age-matched controls
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Morris Eye Group | Encinitas | California | 92024 | United States |
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DNA extracted from whole blood and buccal cells will be analyzed. Remnant samples will be stored for future research in AMD.
| ID | Term |
|---|---|
| D008268 | Macular Degeneration |
| ID | Term |
|---|---|
| D012162 | Retinal Degeneration |
| D012164 | Retinal Diseases |
| D005128 | Eye Diseases |
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