Association of Macular Pigment Optical Density (MPOD) and Genetic Variants in Complement Factor H in Subjects With Choroidal Neovascular (CNV)

Collection of Whole Blood Specimens and Buccal Swabs From Subjects Diagnosed With CNV AMD, Dry AMD, and Age-Matched Controls to Assess the Association of Genetic Variants in Complement Factor H With Risk of Progression to CNV.

Subjects with wet AMD, dry AMD, and age-matched controls will undergo routine occular measurements, will provide a blood and cheek cell sample, and will have macular pigment optical density (MPOD) measured to determine if there is an association between genetics, MPOD and the risk of progression to wet AMD.

Inclusion Criteria:

• subject is diagnosed with either CNV, dry AMD or is an age-matched control
• self reported as non-Hispanic Caucasian
• 60 years of age or older
• provides signed and dated informed consent
• agrees to provide 10 mL of whole blood and two buccal swabs

Exclusion Criteria:

• previous donation under this protocol