Insulin Glulisine and Aspart in Postprandial Glycemic Control After High-GI Meal in Children With Type 1 Diabetes Mellitus

The Impact Of Insulin Glulisine In Comparison With Aspart On Postprandial Glycemia After The High-Glycemic Index Meal In Children With Type 1 Diabetes - Cross-Over Double-Blind, Randomized Clinical Trial.

The aim of this study is to determine whether insulin glulisine is more effective in postprandial glycemic control than insulin aspart after the H-GI meal in children with type 1 diabetes (T1DM) treated with insulin pump (CSII).

Some studies have suggested that insulin glulisine (GLU) has a slightly faster onset of action compared with insulin aspart (ASP). Meals of high glycemic index (H-GI) have distinct effect on postprandial glycaemia (PPG).

Inclusion Criteria:

• Type 1 diabetes mellitus
• CSII for at least 3 months
• Duration of diabetes > 1 years
• Informed consent

Exclusion Criteria:

• Concomitant dietary restrictions (e.g. celiac disease or food allergy)
• Diabetes related complications
• Baseline hyperglycemia >150 mg/dl
• Any disease judged by the investigator to affect the trial