The Effect of Sarpogrelate and High Dose Statin on the Reduction of Coronary Spasm

A Prospective, Single-center, Randomized Study to Evaluate the Effect of Sarpogrelate, a Selective Serotonin Receptor Antagonist, and High Dose Statin on the Reduction of Coronary Spasm in the Patients With Variant Angina

The aim of the study was to to evaluate the effect of sarpogrelate, a selective serotonin receptor antagonist, and high dose statin on the reduction of coronary spasm in the patients with variant angina.

Inclusion Criteria:

• Clinical history of chest pain compatible with variant angina; morning chest pain aggravated by cold exposure.
• Angiographically proven coronary spasm; TIMI flow < 3 by spontaneous coronary spasm or intracoronary ergonovine spasm provocation test.

Exclusion Criteria:

• Cardiac arrest by coronary spasm
• Left main coronary spasm
• Significant fixed coronary artery stenosis; Diameter stenosis > 70% in the major epicardial artery by coronary angiography
• Left ventricular ejection fraction < 30%
• Coagulation disorders or bleeding tendency (Platelet count < 50k, PT INR > 2.0)
• Significant liver disease (AST or ALT > 100 U/ml)
• Renal failure (S-Cr > 2.0 mg/dl)
• hypersensitivity for statin
• Pregnancy