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This study compares the effect of infusion of two types of modern hydroxyethyl starch on the renal function and acid-base in patients undergoing urologic surgery.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| VOL group | Experimental | patients will receive 6% HES 130/0.4 in NaCl 0.9% (Voluven, Fresenius Kabi, Bad Hom-bourg, Germany) |
|
| TET group | Experimental | patient will receive 6% HES 130/0.42 in a balanced electrolyte containing Na+140 mmol/L, Cl- 118 mmol/L, K +4 mmol/L, Ca++ 2.5 mmol/L, Mg++ 1 mmol/L, acetate- 24 mmol/L and malate-- 5 mmol/L |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| 6% HES 130/0.4 in NaCl 0.9% (Voluven, Fresenius Kabi, Bad Hom-bourg, Germany) | Drug |
| ||
| Tetraspan, B. Braun, Melsungen, Germany |
| Measure | Description | Time Frame |
|---|---|---|
| Intraoperative volume replacement therapy | volume of the study drug in milliliters that will be needed for hemodynamic stabilization until the end of surgery (ie, the cumulative volume of the study drug in milliliters administered up to this time point). | From randomization, for the duration of surgery and up to transfer from the operating room to the ICU or recovery room, an expected average of 6 hours |
| Measure | Description | Time Frame |
|---|---|---|
| Acid base and Renal function | differences in the plasma creatinine concentrations and acid-base homeostasis among the study groups | 24 hours after randomization |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Amr Hussein, MSc | Contact | 01069338998 | +2 | amrhussein1981@hotmail.com |
| Ahmed Mukhtar, MD | Contact | 01114208444 | +2 | Ahmed.Mukhtar@kasralainy.edu.eg |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Kasralainy Hospital | Recruiting | Cairo | 11559 | Egypt |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 18813 | Background | Kluft C, Jenks RL, Astrup T. Production of plasminogen actovatpr activity in factor XII-deficient plasma. Thromb Res. 1977 May;10(5):759-64. doi: 10.1016/0049-3848(77)90058-5. No abstract available. | |
| 18633 | Background | Takayanagi I, Maruyama M, Takagi K. Beta-adrenoceptors in the guinea pig treated with egg-albumin. Jpn J Pharmacol. 1977 Apr;27(2):314-6. doi: 10.1254/jjp.27.314. No abstract available. |
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| ID | Term |
|---|---|
| D006895 | Hydroxyethyl Starch Derivatives |
| C485123 | HES 130-0.4 |
| ID | Term |
|---|---|
| D013213 | Starch |
| D004040 | Dietary Carbohydrates |
| D002241 | Carbohydrates |
| D005936 | Glucans |
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| Drug |
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| 10319 | Background | Mitchell AR, Erickson BW, Ryabtsev MN, Hodges RS, Merrifield RB. Tert-butoxycarbonylaminoacyl-4-(oxymethyl)-phenylacetamidomethyl-resin, a more acid-resistant support for solid-phase peptide synthesis. J Am Chem Soc. 1976 Nov 10;98(23):7357-62. doi: 10.1021/ja00439a041. No abstract available. |
| 21345 | Background | Birke ER. [On the action of antihypotensive agents in sympathicotonic orthostatic hypotension in geriartric patients: comparison between placebo and etilefrin (author's transl)]. Med Klin. 1977 Oct 14;72(41):1696-702. German. |
| D011134 |
| Polysaccharides |