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This was a multicenter, multi-reader, open-label, Phase 2 study assessing the safety and performance characteristics of MIP 1404 imaging in the detection of prostate gland and pelvic lymph node cancer. Comparative performance characteristics between MIP 1404 imaging and MRI were also assessed, as judged by histopathology results.
This is a single arm, open label study of approximately 100 high-risk prostate cancer patients scheduled for prostatectomy and extended pelvic lymph node dissection. Patients receive a single IV dose of 99mTc-MIP-1404 (study drug) followed by SPECT/CT scan 3-6 hours after injection. As standard of care, patients will undergo prostatectomy and extended pelvic lymph node dissection (EPLND) within three weeks of study drug dosing. 99mTc-MIP-1404 image data will be evaluated for visible uptake and compared with histopathology.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Drug: 99mTc-MIP-1404 | Experimental | 20 ±3 mCi intravenous (IV) injection of 99mTc-MIP-1404 |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Drug: 99mTc-MIP-1404 | Drug | A single dose of 20 ±3 mCi intravenous (IV) injection of 99mTc-MIP-1404 |
|
| Measure | Description | Time Frame |
|---|---|---|
| Assess the Ability of 99mTc-MIP-1404 to Detect Prostate Cancer Within the Prostate Gland. | For the prostate gland, sensitivity values refer to the number of subjects in the study, i.e., the percentages of true positive subjects correctly identified by the imaging technique. Pathology results were used as the truth standard for all imaging analyses. | Within 3-6 hours of dosing SPECT/CT images will be taken |
| Measure | Description | Time Frame |
|---|---|---|
| Assess the Ability of MIP-1404 to Detect Metastatic Prostate Cancer Within Pelvic Lymph Nodes | For lymph nodes, sensitivity values refer to the number of subjects in the study, i.e., the percentages of true positive subjects correctly identified by the imaging technique. Pathology results were used as the truth standard for all imaging analyses. | Within 3-6 hours of dosing SPECT/CT images will be taken |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Douglas Scherr, M.D. | New York Presbyterian Hospital-Cornell | Principal Investigator |
| Jeffrey Karnes, MD | Mayo Clinic | Principal Investigator |
| Kevin Slawin, MD | University of Texas Vanguard Urologic Research Foundation | Principal Investigator |
| Thomas Keane, MD | Medical University of South Carolina | Principal Investigator |
| Edouard Trabulsi, MD | Thomas Jefferson University / Jefferson Urology Associates | Principal Investigator |
| David Jarrard, MD | University of Wisconsin, Madison | Principal Investigator |
| William Ellis, MD | University of Washington | Principal Investigator |
| Judd Moul, MD | Duke University | Principal Investigator |
| Eric Klein, MD | Glickman Urology & Kidney Institute, Cleveland Clinic | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| City of Hope National Cancer Center | Duarte | California | 91010 | United States | ||
| Mayo Clinic |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| Background | American Cancer Society, Inc., Surveillance Research; Cancer Facts & Figures, 2012 | ||
| 21296855 | Background | Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D. Global cancer statistics. CA Cancer J Clin. 2011 Mar-Apr;61(2):69-90. doi: 10.3322/caac.20107. Epub 2011 Feb 4. | |
| 18325358 |
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| ID | Title | Description |
|---|---|---|
| FG000 | Drug: 99mTc-MIP-1404 | 20 ±3 mCi intravenous (IV) injection of 99mTc-MIP-1404 Drug: 99mTc-MIP-1404: A single dose of 20 ±3 mCi intravenous (IV) injection of 99mTc-MIP-1404 |
| Title | Milestones | Reasons Not Completed | |||||
|---|---|---|---|---|---|---|---|
| Overall Study |
|
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| Assess the Ability of MIP-1404 to Detect the Extent and Location of Prostate Cancer Within the Prostate Gland | For specific segments of the prostate, a sensitivity value refers to the number of evaluable segments (histologically examined "tissue-segments") from all subjects, i.e., the percentages of true positive segments correctly identified by the imaging technique. | Within 3-6 hours of dosing SPECT/CT images will be taken |
| Assess the Ability of MIP-1404 to Detect the Specific Location of Metastatic Prostate Cancer Within Anatomic Pelvic Lymph Node Regions | For specific segments of the lymph nodes, a sensitivity value refers to the number of evaluable segments (histologically examined "tissue-segments") from all subjects, i.e., the percentages of true positive segments correctly identified by the imaging technique. | Within 3-6 hours of dosing SPECT/CT images will be taken |
| Assess the Comparative Performance of MIP-1404 Against MRI for Detection of Prostate Cancer Within the Prostate Gland. | Comparative performance characteristics between MIP-1404 imaging and MRI were analyzed for the prostate gland. MIP-1404 and MRI sensitivities were derived from case positive histopathology results. | Within 3-6 hours of dosing SPECT/CT images will be taken |
| Assess the Comparative Performance of MIP-1404 Against MRI for Detection of Metastatic Prostate Cancer Within Pelvic Lymph Nodes. | Comparative performance characteristics between MIP-1404 imaging and MRI were analyzed for the lymph nodes. MIP-1404 and MRI sensitivities were derived from case positive histopathology results. | Within 3-6 hours of dosing SPECT/CT images will be taken |
| Bertram Yuh, MD | City of Hope National Cancer Center | Principal Investigator |
| Steven Joniau, MD | Universitaire Ziekenhuizen KU Leuven | Principal Investigator |
| Alberto Briganti, MD | Vita-Salute University San Raffaele | Principal Investigator |
| Paolo Gontero, MD | University of Turin, Italy | Principal Investigator |
| Mikhail I Shkolnik, MD | Federal State Public Institution Russian Research center for Radiology and Surgical Technologies under the Federal agency for High-tech medical care | Principal Investigator |
| Petr A Karlov, MD | St. Petersburg State Public Medical Institution: "Clinical Oncological Center" | Principal Investigator |
| Vsevolod B Matveev, MD | Federal Public State Institution "Russian Oncology Research Center n.a. N.N. Blokhin under the Russian Academy of medical sciences" | Principal Investigator |
| Boris Ya Alexeev, MD | Moscow Oncology Research Institute n.a. P.A. Hertsen | Principal Investigator |
| Sergey V Mishugin, MD | City Clinical Hospital # 57 | Principal Investigator |
| Oleg B Karyakin | Federal State Public Institution "Medical Radiology Research Center" of Healthcare Ministry and Social Development of Russian Federation | Principal Investigator |
| Alexander K Nosov, MD | Research Institute of Oncology n.a. Professor N.N. Petrov under the Federal Agency for Healthcare and Social Development | Principal Investigator |
| Sergey B Petrov, MD | All-Russia Centre for Urgent Care and Radiation Medicine named after A.M. Nikiforov under the Ministry of the Russian Federation for Civil Defence, Emergencies and Elimination of Consequences of Natural Disasters | Principal Investigator |
| Milan Hora, MD, PhD | University Hospital Plzen, Department of Urology | Principal Investigator |
| Josef Stolz, MD | University Hospital Motol, Clinic of Urology | Principal Investigator |
| Vladimir Student, MD, PhD | University Hospital Olomouc, Clinic of Urology | Principal Investigator |
| Marek Krolupper, MD | Hospital Na Bulovce, Department of Urology | Principal Investigator |
| Michael Pesl,, MD | General University Hospital in Prague, Clinic of Urology | Principal Investigator |
| Roman Zachoval,, MD, PhD, MBA | Thomayer's Hospital | Principal Investigator |
| Marcin Matuszewski, MD, PhD | University Clinical Centre, Department of Urology | Principal Investigator |
| Henryk Zielinski, MD | University Hospital Plzen, Department of Urology | Principal Investigator |
| Jerzy Sokolowski, MD, PhD | Provincial Specialist Hospital in Wroclaw, Department of Urology | Principal Investigator |
| Tomasz Szydelko, MD, PhD | 4th Military Teaching Hospital and Polyclinic, | Principal Investigator |
| Geza Boszormenyi-Nagy, MD | Bajcsy-Zsilinszky Hospital, Department of Urology | Principal Investigator |
| Peter Tenke, MD | Jahn Ferenc South Pest Hospital, Department of Urology | Principal Investigator |
| Istvan Buzogany, MD | Peterfy Sandor Street Hospital, Department of Urology | Principal Investigator |
| Michiel Sedelaar, MD | UMC St. Radboud Nijmegen | Principal Investigator |
| Rochester |
| Minnesota |
| 55905 |
| United States |
| New York Presbyterian Hospital - Cornell | New York | New York | 10021 | United States |
| Duke University Medical Center | Durham | North Carolina | 27710 | United States |
| Glickman Urology & Kidney Institute, Cleveland Clinic | Cleveland | Ohio | 44195 | United States |
| Thomas Jefferson University / Jefferson Urology Associates | Philadelphia | Pennsylvania | 19107 | United States |
| Medical University of South Carolina | Charleston | South Carolina | 29435 | United States |
| University of Texas Vanguard Urologic Research Foundation | Houston | Texas | 77030 | United States |
| University of Washington School of Medicine | Seattle | Washington | 98109 | United States |
| University of Wisconsin | Madison | Wisconsin | 53792 | United States |
| University Hospitals Leuven | Leuven | 3000 | Belgium |
| University Hospital Olomouc, Clinic of Urology | Olomouc | 779 00 | Czechia |
| University Hospital Plzen, Department of Urology | Pilsen | 30599 | Czechia |
| General University Hospital in Prague, Clinic of Urology | Prague | 128 08 | Czechia |
| Thomayer's Hospital | Prague | 140 59 | Czechia |
| University Hospital Motol, Clinic of Urology | Prague | 15006 | Czechia |
| Hospital Na Bulovce, Department of Urology | Prague | 180 01 | Czechia |
| Bajcsy-Zsilinszky Hospital, Department of Urology | Budapest | 8991 | Hungary |
| Peterfy Sandor Street Hospital, Department of Urology | Budapest | H-1076 | Hungary |
| Jahn Ferenc South Pest Hospital, Department of Urology | Budapest | H1204 | Hungary |
| Vita-Salute University San Raffaele | Milan | 20132 | Italy |
| University of Turin | Torino | 10126 | Italy |
| UMC St. Radboud Nijmegen | Nijmegen | 6525 GA | Netherlands |
| University Clinical Centre, Department of Urology | Gdansk | 80952 | Poland |
| University Hospital Plzen, Department of Urology | Warsaw | 00909 | Poland |
| 4th Military Teaching Hospital and Polyclinic, | Wroclaw | 50981 | Poland |
| "Provincial Specialist Hospital in Wroclaw, Department of Urology | Wroclaw | 51124 | Poland |
| City Clinical Hospital # 57 | Moscow | 105077 | Russia |
| Federal Public State Institution "Russian Oncology Research Center n.a. N.N. Blokhin under the Russian Academy of medical sciences" | Moscow | 115478 | Russia |
| Moscow Oncology Research Institute n.a. P.A. Hertsen | Moscow | 125284 | Russia |
| Federal State Public Institution "Medical Radiology Research Center" of Healthcare Ministry and Social Development of Russian Federation | Obninsk | 249036 | Russia |
| All-Russia Centre for Urgent Care and Radiation Medicine named after A.M. Nikiforov under the Ministry of the Russian Federation for Civil Defence, Emergencies and Elimination of Consequences of Natural Disasters | Saint Petersburg | 197374 | Russia |
| Federal State Public Institution Russian Research center for Radiology and Surgical Technologies under the Federal agency for High-tech medical care | Saint Petersburg | 197758 | Russia |
| Research Institute of Oncology n.a. Professor N.N. Petrov under the Federal Agency for Healthcare and Social Development | Saint Petersburg | 197758 | Russia |
| St. Petersburg State Public Medical Institution: "Clinical Oncological Center" | Saint Petersburg | 198255 | Russia |
| Background |
| Hovels AM, Heesakkers RA, Adang EM, Jager GJ, Strum S, Hoogeveen YL, Severens JL, Barentsz JO. The diagnostic accuracy of CT and MRI in the staging of pelvic lymph nodes in patients with prostate cancer: a meta-analysis. Clin Radiol. 2008 Apr;63(4):387-95. doi: 10.1016/j.crad.2007.05.022. Epub 2008 Feb 4. |
| 9816319 | Background | Pinto JT, Suffoletto BP, Berzin TM, Qiao CH, Lin S, Tong WP, May F, Mukherjee B, Heston WD. Prostate-specific membrane antigen: a novel folate hydrolase in human prostatic carcinoma cells. Clin Cancer Res. 1996 Sep;2(9):1445-51. |
| 11016653 | Background | Smith-Jones PM, Vallabahajosula S, Goldsmith SJ, Navarro V, Hunter CJ, Bastidas D, Bander NH. In vitro characterization of radiolabeled monoclonal antibodies specific for the extracellular domain of prostate-specific membrane antigen. Cancer Res. 2000 Sep 15;60(18):5237-43. |
| 16555021 | Background | Kinoshita Y, Kuratsukuri K, Landas S, Imaida K, Rovito PM Jr, Wang CY, Haas GP. Expression of prostate-specific membrane antigen in normal and malignant human tissues. World J Surg. 2006 Apr;30(4):628-36. doi: 10.1007/s00268-005-0544-5. |
| 9840525 | Background | Murphy GP, Elgamal AA, Su SL, Bostwick DG, Holmes EH. Current evaluation of the tissue localization and diagnostic utility of prostate specific membrane antigen. Cancer. 1998 Dec 1;83(11):2259-69. |
| 14755683 | Background | Ghosh A, Heston WD. Tumor target prostate specific membrane antigen (PSMA) and its regulation in prostate cancer. J Cell Biochem. 2004 Feb 15;91(3):528-39. doi: 10.1002/jcb.10661. |
| 17320151 | Background | Perner S, Hofer MD, Kim R, Shah RB, Li H, Moller P, Hautmann RE, Gschwend JE, Kuefer R, Rubin MA. Prostate-specific membrane antigen expression as a predictor of prostate cancer progression. Hum Pathol. 2007 May;38(5):696-701. doi: 10.1016/j.humpath.2006.11.012. Epub 2007 Feb 22. |
| 9815541 | Background | Silver DA, Pellicer I, Fair WR, Heston WD, Cordon-Cardo C. Prostate-specific membrane antigen expression in normal and malignant human tissues. Clin Cancer Res. 1997 Jan;3(1):81-5. |
| 9694964 | Background | Luthi-Carter R, Barczak AK, Speno H, Coyle JT. Molecular characterization of human brain N-acetylated alpha-linked acidic dipeptidase (NAALADase). J Pharmacol Exp Ther. 1998 Aug;286(2):1020-5. |
| 7665226 | Background | Troyer JK, Beckett ML, Wright GL Jr. Detection and characterization of the prostate-specific membrane antigen (PSMA) in tissue extracts and body fluids. Int J Cancer. 1995 Sep 4;62(5):552-8. doi: 10.1002/ijc.2910620511. |
| 10397265 | Background | Chang SS, Reuter VE, Heston WD, Bander NH, Grauer LS, Gaudin PB. Five different anti-prostate-specific membrane antigen (PSMA) antibodies confirm PSMA expression in tumor-associated neovasculature. Cancer Res. 1999 Jul 1;59(13):3192-8. |
| 19111054 | Background | Maresca KP, Hillier SM, Femia FJ, Keith D, Barone C, Joyal JL, Zimmerman CN, Kozikowski AP, Barrett JA, Eckelman WC, Babich JW. A series of halogenated heterodimeric inhibitors of prostate specific membrane antigen (PSMA) as radiolabeled probes for targeting prostate cancer. J Med Chem. 2009 Jan 22;52(2):347-57. doi: 10.1021/jm800994j. |
| 19706750 | Background | Hillier SM, Maresca KP, Femia FJ, Marquis JC, Foss CA, Nguyen N, Zimmerman CN, Barrett JA, Eckelman WC, Pomper MG, Joyal JL, Babich JW. Preclinical evaluation of novel glutamate-urea-lysine analogues that target prostate-specific membrane antigen as molecular imaging pharmaceuticals for prostate cancer. Cancer Res. 2009 Sep 1;69(17):6932-40. doi: 10.1158/0008-5472.CAN-09-1682. Epub 2009 Aug 25. |
| 21257258 | Background | Godoy G, Chong KT, Cronin A, Vickers A, Laudone V, Touijer K, Guillonneau B, Eastham JA, Scardino PT, Coleman JA. Extent of pelvic lymph node dissection and the impact of standard template dissection on nomogram prediction of lymph node involvement. Eur Urol. 2011 Aug;60(2):195-201. doi: 10.1016/j.eururo.2011.01.016. Epub 2011 Jan 18. |
| 1637980 | Background | Rao JN, Scott AJ. A simple method for the analysis of clustered binary data. Biometrics. 1992 Jun;48(2):577-85. |
| 12520562 | Background | Durkalski VL, Palesch YY, Lipsitz SR, Rust PF. Analysis of clustered matched-pair data for a non-inferiority study design. Stat Med. 2003 Jan 30;22(2):279-90. doi: 10.1002/sim.1385. |
| 23733925 | Derived | Hillier SM, Maresca KP, Lu G, Merkin RD, Marquis JC, Zimmerman CN, Eckelman WC, Joyal JL, Babich JW. 99mTc-labeled small-molecule inhibitors of prostate-specific membrane antigen for molecular imaging of prostate cancer. J Nucl Med. 2013 Aug;54(8):1369-76. doi: 10.2967/jnumed.112.116624. Epub 2013 Jun 3. |
| COMPLETED |
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| NOT COMPLETED |
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| ID | Title | Description |
|---|---|---|
| BG000 | Drug: 99mTc-MIP-1404 | 20 ±3 mCi intravenous (IV) injection of 99mTc-MIP-1404 Drug: 99mTc-MIP-1404: A single dose of 20 ±3 mCi intravenous (IV) injection of 99mTc-MIP-1404 |
| Units | Counts |
|---|---|
| Participants |
|
| Title | Description | Population Description | Parameter Type | Dispersion Type | Unit of Measure | Calculate Percentage | Denominator Units Selected | Denominators | Classes | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Age, Continuous | Mean | Standard Deviation | years |
| |||||||||||||||||
| Gender | Count of Participants | Participants |
|
| Type | Title | Description | Population Description | Reporting Status | Anticipated Posting Date | Parameter Type | Dispersion Type | Unit of Measure | Calculate Percentage | Time Frame | Units Analyzed | Denominator Units Selected | Arm/Group Information | Denominators | Classes | Analyses | ||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Primary | Assess the Ability of 99mTc-MIP-1404 to Detect Prostate Cancer Within the Prostate Gland. | For the prostate gland, sensitivity values refer to the number of subjects in the study, i.e., the percentages of true positive subjects correctly identified by the imaging technique. Pathology results were used as the truth standard for all imaging analyses. | The primary analysis population is defined as all subjects who completed prostate and lymph node SPECT/CT MIP-1404 imaging, underwent EPLND, and had histopathology results. This population is one less than the safety population (n=105) | Posted | Number | 90% Confidence Interval | % sensitivity | Within 3-6 hours of dosing SPECT/CT images will be taken |
|
|
| |||||||||||||||||||||||||
| Secondary | Assess the Ability of MIP-1404 to Detect Metastatic Prostate Cancer Within Pelvic Lymph Nodes | For lymph nodes, sensitivity values refer to the number of subjects in the study, i.e., the percentages of true positive subjects correctly identified by the imaging technique. Pathology results were used as the truth standard for all imaging analyses. | The primary analysis population, defined as all subjects who completed prostate and lymph node SPECT/CT MIP-1404 imaging, underwent EPLND, and had histopathology results, was used for this endpoint. A total of 3025 nodes were removed from 103 subjects (mean 29.6, range 1-88). Of these, 79 nodes were positive by pathology in 33 subjects. | Posted | Number | 90% Confidence Interval | % sensitivity | Within 3-6 hours of dosing SPECT/CT images will be taken |
|
| ||||||||||||||||||||||||||
| Secondary | Assess the Ability of MIP-1404 to Detect the Extent and Location of Prostate Cancer Within the Prostate Gland | For specific segments of the prostate, a sensitivity value refers to the number of evaluable segments (histologically examined "tissue-segments") from all subjects, i.e., the percentages of true positive segments correctly identified by the imaging technique. | The primary analysis population is defined as all subjects who completed prostate and lymph node SPECT/CT MIP-1404 imaging, underwent EPLND, and had histopathology results. This population is one less than the safety population (n=105) | Posted | Number | 90% Confidence Interval | % sensitivity | Within 3-6 hours of dosing SPECT/CT images will be taken | Prostate Segments | Prostate Segments |
|
| ||||||||||||||||||||||||
| Secondary | Assess the Ability of MIP-1404 to Detect the Specific Location of Metastatic Prostate Cancer Within Anatomic Pelvic Lymph Node Regions | For specific segments of the lymph nodes, a sensitivity value refers to the number of evaluable segments (histologically examined "tissue-segments") from all subjects, i.e., the percentages of true positive segments correctly identified by the imaging technique. | The primary analysis population is defined as all subjects who completed prostate and lymph node SPECT/CT MIP-1404 imaging, underwent EPLND, and had histopathology results. This population is one less than the safety population (n=105) | Posted | Number | 90% Confidence Interval | % sensitivity | Within 3-6 hours of dosing SPECT/CT images will be taken | Lymph Node Segments | Lymph Node Segments |
|
| ||||||||||||||||||||||||
| Secondary | Assess the Comparative Performance of MIP-1404 Against MRI for Detection of Prostate Cancer Within the Prostate Gland. | Comparative performance characteristics between MIP-1404 imaging and MRI were analyzed for the prostate gland. MIP-1404 and MRI sensitivities were derived from case positive histopathology results. | All subjects who completed prostate SPECT/CT MIP-1404 and MRI imaging and had histopathology results. | Posted | Number | % specificity | Within 3-6 hours of dosing SPECT/CT images will be taken |
|
| |||||||||||||||||||||||||||
| Secondary | Assess the Comparative Performance of MIP-1404 Against MRI for Detection of Metastatic Prostate Cancer Within Pelvic Lymph Nodes. | Comparative performance characteristics between MIP-1404 imaging and MRI were analyzed for the lymph nodes. MIP-1404 and MRI sensitivities were derived from case positive histopathology results. | All subjects who completed lymph node SPECT/CT MIP-1404 and MRI imaging, underwent EPLND, and had histopathology results. | Posted | Number | % sensitivity | Within 3-6 hours of dosing SPECT/CT images will be taken |
|
|
Day 0 (day of dosing) to Day 21 post study drug injection.
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| ID | Title | Description | Deaths (Affected) | Deaths (At Risk) | Serious Events (Affected) | Serious Events (At Risk) | Other Events (Affected) | Other Events (At Risk) |
|---|---|---|---|---|---|---|---|---|
| EG000 | Drug: 99mTc-MIP-1404 | 20 ±3 mCi intravenous (IV) injection of 99mTc-MIP-1404 Drug: 99mTc-MIP-1404: A single dose of 20 ±3 mCi intravenous (IV) injection of 99mTc-MIP-1404 | 0 | 105 | 0 | 105 |
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| Title | Organization | Phone | Extension | |
|---|---|---|---|---|
| Senior Director, Clinical Science Communications | Progenics Pharmaceuticals, Inc. | 914 784-1825 | vdipippo@progenics.com |
| ID | Term |
|---|---|
| D011471 | Prostatic Neoplasms |
| ID | Term |
|---|---|
| D005834 | Genital Neoplasms, Male |
| D014565 | Urogenital Neoplasms |
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
| D005832 | Genital Diseases, Male |
| D000091662 | Genital Diseases |
| D000091642 | Urogenital Diseases |
| D011469 | Prostatic Diseases |
| D052801 | Male Urogenital Diseases |
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| ID | Term |
|---|---|
| C000595576 | technetium 99m 1-(1-(2-(bis(carboxymethyl)amino)-2-oxoethyl)-1H-imidazol-2-yl)-2-((1-(2-(bis(carboxymethyl)amino)-2-oxoethyl)-1H-imidazol-2-yl)methyl)-9,14-dioxo-2,8,13,15-tetraazaoctadecane-7,12,16,18-tetracarboxylic acid) |
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|
| Prostate Segments |
|
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| Lymph Node Segments |
|
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|
|