This trial is a single-blind, cross-over design. Up to three patients with confirmed metastatic prostate adenocarcinoma and up to three healthy volunteers will receive two doses of 20.0 (± 3) mCi of intravenously administered 99mTc MIP 1404 (preparation A or preparation B). Whole-body planar scintigraphic images will be acquired at various time points on the day of study drug administration. A pelvic SPECT/CT image will be acquired on the day of study drug administration. Blood will be collected for pharmacokinetic measurements following study drug administration. Each participant will receive an initial study drug administration (preparation A) and a second study drug administration (preparation B) approximately 7 to 21 days later. A final follow-up visit will occur approximately 2 - 3 weeks after the second study drug administration.

Inclusion Criteria:

• Male aged 21 years or older.
• Ability to provide signed informed consent and willingness to comply with protocol requirements.
• Participants must agree to use an acceptable form of birth control throughout the study period. Participants must agree to use condoms for a period of seven days after each study drug administration, if engaged in sexual activity.

Additional Inclusion Criteria for Metastatic Prostate Adenocarcinoma Patients:

• Histologic diagnosis of prostate cancer by validated medical history (pathology report, if available).
• Evidence of metastatic disease demonstrated by a documented abnormal bone scan, CT scan, or MRI
• Karnofsky performance is ≥ 60

Additional Inclusion Criteria for Healthy Volunteers:

• PSA laboratory assessment within normal range (PSA < 4 ng/ml)
• Normal findings on a digital rectal examination
• Hemoglobin and hematocrit within normal range

Exclusion Criteria:

• Received a radioisotope within 5 physical half lives of that radioisotope prior to study enrollment
• Have any medical condition or other circumstances which, in the opinion of the Investigator, would significantly decrease the chances of obtaining reliable data, achieving study objectives, or completing the study and/or post dose follow-up examinations
• Participant is determined by the Investigator to be clinically unsuitable for the study
• Serum creatinine ≥ 2.0 mg/dl
• Total bilirubin ≥ 2.0 mg/dl
• Liver transaminases ≥ 1.5 x ULN
• Platelet count < 100,000/mm3
• Absolute neutrophil count (ANC) < 2,000/mm3
• Hematocrit < 30% or hemoglobin < 10 g/dl

Additional Exclusion Criteria for Metastatic Prostate Adenocarcinoma Patients:

• Have received a permanent prostate brachytherapy implant within the last 3 months for 103Pd implants; or 12 months for 125I implants
• Have had any other malignancies within the past year, other than basal or squamous cell carcinoma of the skin, in which the diagnosis and location have not been defined as clinically controlled or treated to complete response