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| Name | Class |
|---|---|
| The Wright Group in Crowley, LA | UNKNOWN |
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The purpose of this study is to see if rice enriched in iron will help women with iron-deficient anemia restore their blood counts more efficiently than the standard rice not enriched with iron.
The study will consist of 1 screening visit and 3 study visits. The two-week study will be scheduled to be between menses.
You will then be assigned to eat regular rice dishes or rice dishes fortified with iron for the two-week period. The assignment to the rice group will be made randomly (like flipping a coin). Your chance of being in either rice group will be 50:50. You will be given 14 frozen rice meals in styrofoam containers to take home. You will be expected to eat two rice dishes per day for the next study week and to bring the empty containers to your next study visit.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Regular Rice | Other | 2 servings per day of non-fortified rice |
|
| Iron-fortified Rice | Other | 2 servings per day of Rice enriched in iron for women with iron-deficient anemia to restore their blood counts more efficiently than the standard rice not enriched with iron. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Non-fortified rice | Other | Consumption of 2 servings of Non-fortified rice per day in women with iron deficiency anemia and measure serum iron and transferrin at baseline and end of study. |
| Measure | Description | Time Frame |
|---|---|---|
| Change in reticulocyte count. | Change in reticulocyte typically count in the iron-fortified rice group compared to the regular rice group. This is a test that measures how rapidly immature red blood cells called reticulocytes are made by the bone marrow and released into the blood. | Baseline and 1 and 2 weeks following consumption of 2 servings |
| Measure | Description | Time Frame |
|---|---|---|
| Changes in serum iron | Changes in serum iron is a medical laboratory test that measures the amount of circulating iron in the blood; in the fortified rice group compared to the regular rice group. | Baseline and 1 and 2 weeks following consumption |
| Transferrin |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Frank L. Greenway, MD | Pennington Biomedical Research Center | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Pennington Biomedical Research Center | Baton Rouge | Louisiana | 70808 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 28966915 | Result | Losso JN, Karki N, Muyonga J, Wu Y, Fusilier K, Jacob G, Yu Y, Rood JC, Finley JW, Greenway FL. Iron retention in iron-fortified rice and use of iron-fortified rice to treat women with iron deficiency: A pilot study. BBA Clin. 2017 Sep 8;8:78-83. doi: 10.1016/j.bbacli.2017.09.001. eCollection 2017 Dec. |
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| ID | Term |
|---|---|
| D018798 | Anemia, Iron-Deficiency |
| ID | Term |
|---|---|
| D000747 | Anemia, Hypochromic |
| D000740 | Anemia |
| D006402 | Hematologic Diseases |
| D006425 | Hemic and Lymphatic Diseases |
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| Iron-fortified Rice | Other | Consumption of 2 servings of Iron-fortified rice per day in women with iron deficiency anemia and measure serum iron and transferrin at baseline and end of study. |
|
Changes in transferrin (a protein that transports iron in the body ) in the fortified rice group compared to the regular rice group. |
| Baseline and 1 and 2 weeks following consumption |
| Hemoglobin | Changes in hemoglobin (The key protein in red blood cells to which oxygen attaches) in the fortified rice group compared to the regular rice group. | Baseline and 1 and 2 weeks following consumption |
| Hematocrit | Changes in hematocrit (the proportion of your total blood volume that is composed of red blood cells) in the fortified rice group compared to the regular rice group. | Baseline and 1 and 2 weeks following consumption |
| Mean Corpuscular Volume | Changes in mean corpuscular volume (the average red blood cell size in the fortified rice group compared to the regular rice group. | Baseline and 1 and 2 weeks following consumption |
| D000090463 |
| Iron Deficiencies |
| D019189 | Iron Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |