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| Name | Class |
|---|---|
| PATH | OTHER |
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Investigation of Iron Bioavailability from extruded rice grains fortified with Ferric Pyrophosphate alone or in combination with different Zinc Compounds; Ferrous Sulfate serves as a Reference.
Ferric Pyrophosphate (FePP) is a water-insoluble, food grade, iron compound widely used to fortify rice and other foods as it causes no organoleptic changes to the food vehicles. However, it is only of low absorption in man and its absorption can be influenced by a variety of compounds. The effect of co-fortification of rice with ZnO respectively ZnSO4 on iron bioavailability in extruded rice fortified with FePP has never been investigated.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Iron fortified rice | Experimental | Administration of iron fortified rice to all subjects; subjects will act as their own controls and each subject will receive all foreseen treatments/interventions. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Ferric Pyrophosphate and Zinc Oxide | Other | Rice fortified with Ferric Pyrophosphate and Zinc Oxide (ZnO) |
|
| Measure | Description | Time Frame |
|---|---|---|
| Change from baseline in the isotopic ratio of iron in blood at week 2 | The change in the isotopic ratio of iron will be measured after the administration of test meal including iron isotopes. | baseline, 2 weeks |
| Change from week 2 in the isotopic ratio of iron in blood at week 4 | The change in the isotopic ratio of iron will be measured after the administration of test meal including iron isotopes. | 2 weeks, 4 weeks |
| Change from week 4 in the isotopic ratio of iron in blood at week 6 | The change in the isotopic ratio of iron will be measured after the administration of test meal including iron isotopes. | 4 weeks, 6 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Haemoglobin | 14 or 15 days after each meal administration and at baseline | baseline, 16th, 30th and 44th day |
| Plasma Ferritin | 14 or 15 days after each meal administration and at baseline |
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Inclusion Criteria:
Exclusion Criteria:
-
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| Name | Affiliation | Role |
|---|---|---|
| Michael Zimmermann, Prof.Dr., MD | ETH Zürich | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| ETH Zürich, Laboratory of Human Nutrition | Zurich | Canton of Zurich | 8092 | Switzerland |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 28148685 | Derived | Hackl L, Zimmermann MB, Zeder C, Parker M, Johns PW, Hurrell RF, Moretti D. Iron Bioavailability from Ferric Pyrophosphate in Extruded Rice Cofortified with Zinc Sulfate Is Greater than When Cofortified with Zinc Oxide in a Human Stable Isotope Study. J Nutr. 2017 Mar;147(3):377-383. doi: 10.3945/jn.116.241778. Epub 2017 Feb 1. |
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| Ferrous sulfate | Other | Rice fortified with Ferrous Sulfate (ZnSO4) |
|
| Ferric Pyrophosphate and Zinc Sulfate | Other | Rice fortified with Ferric Pyrophosphate and Zinc Sulfate |
|
| Ferric Pyrophosphate | Other | Rice fortified with Ferric Pyrophosphate |
|
| baseline, 16th, 30th and 44th day |
| C reactive protein | 14 or 15 days after each meal administration and at baseline | baseline, 16th, 30th and 44th day |
| ID | Term |
|---|---|
| D000090463 | Iron Deficiencies |
| ID | Term |
|---|---|
| D019189 | Iron Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
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| ID | Term |
|---|---|
| C049051 | ferric pyrophosphate |
| D015034 | Zinc Oxide |
| C020748 | ferrous sulfate |
| D019287 | Zinc Sulfate |
| ID | Term |
|---|---|
| D010087 | Oxides |
| D017601 | Oxygen Compounds |
| D007287 | Inorganic Chemicals |
| D017967 | Zinc Compounds |
| D013431 | Sulfates |
| D013464 | Sulfuric Acids |
| D013456 | Sulfur Acids |
| D013457 | Sulfur Compounds |
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