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| Name | Class |
|---|---|
| Pontificia Universidade Católica do Rio Grande do Sul | OTHER |
Aim: To assess in vivo if the intake of yogurt containing Bifidobacterium animalis ssp. lactis DN- 1173010 probiotic for a period of 2 weeks affects the salivary levels or biofilms of mutans streptococci and the lactobacilli of patients undergoing orthodontic treatment. Methods: A crossover, double-blind, randomized and placebo controlled clinical trial will be performed with 26 volunteers during 4 periods. During periods 2 and 4 (2 weeks each) the volunteers will have a daily ingestion of yogurt containing probiotic or of control yogurt which did not contain probiotic. Periods 1 and 3 were run-in and wash-out periods of 1 and 4 weeks, respectively. Experimental samples of saliva and biofilm will be collected from each participant at the end of each phase. Mutans streptococci, lactobacilli, total aciduric microorganisms, Candida spp. and total cultivable microorganisms will be counted. The values before and after the treatment will be compared with Wilcoxon's test (p<0.05).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Probiotics | Experimental | Group of patients using yogurt containing probiotics during the experimental phase of the study. |
|
| Control Yogurt | Placebo Comparator | Group of patients that will use a placebo yogurt for providing comparison with the experimental group. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Yogurt containing probiotics | Dietary Supplement | patients assigned to this group will use a yogurt containing Bifidobacterium animalis once a day during 14 days before evaluation of the outcomes. |
| Measure | Description | Time Frame |
|---|---|---|
| Cariogenic bacteria reduction | The amount of cariogenic bacteria (mutans streptococci and lactobacilli) will be evaluated before and after the treatments for each patient | 14 days |
| Measure | Description | Time Frame |
|---|---|---|
| Patient discomfort with the treatment | Patients were interviewed regarding any discomfort on the use of the treatments | 14 days after intervention |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Maximiliano S Cenci, PhD | Graduate Program in Dentistry, Federal University of Pelotas | Study Chair |
| Gabriela S Pinto, MSc | Graduate Program in Dentistry, Federal University of Pelotas | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Graduate Program in Dentistry, Federal University of Pelotas | Pelotas | Rio Grande do Sul | 96015560 | Brazil |
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| ID | Term |
|---|---|
| D003731 | Dental Caries |
| ID | Term |
|---|---|
| D017001 | Tooth Demineralization |
| D014076 | Tooth Diseases |
| D009057 | Stomatognathic Diseases |
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| ID | Term |
|---|---|
| D015014 | Yogurt |
| D019936 | Probiotics |
| ID | Term |
|---|---|
| D043302 | Cultured Milk Products |
| D008892 | Milk |
| D001628 | Beverages |
| D000066888 | Diet, Food, and Nutrition |
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| Placebo yogurt | Dietary Supplement | Patients will use a yogurt without probiotics once a day during 14 days before evaluation of outcomes |
|
|
| D010829 |
| Physiological Phenomena |
| D000074421 | Fermented Foods |
| D003611 | Dairy Products |
| D005502 | Food |
| D019602 | Food and Beverages |
| D019587 | Dietary Supplements |