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Hypoxia frequently develops during one lung ventilation in the supine position.The objective of this article is to study the impact of preemptive alveolar recruitment and subsequent positive end expiratory pressure on arterial oxygenation and lung mechanics during one lung ventilation in the supine position in patients undergoing thoracic surgery .
outcome measures: respiratory parameters (Paw, Ppla, Compliance, Vd/Vt)and oxygenation parameters (PaO2, shunt fraction, Pa-AO2)
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Control | No Intervention | zero PEEP | |
| OLV strategy: PEEP | Experimental | 1. apply 8 cm H2O positive end expiratory pressure during one lung ventilation and until the end of surgery |
|
| OLV strategy: PEEP followed by AR | Experimental |
|
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| PEEP | Other | 8 cmH2O PEEP throughout the period of OLV and 2nd TLV |
|
| Measure | Description | Time Frame |
|---|---|---|
| PaO2, number of patients with hypoxia (PaO2< 90mmHg) | blood samplings after induction of anesthesia, 15 and 30 min after OLV, after the 2nd TLV | participants will be followed for the duration of anesthesia, an expected average of 3 hours |
| Measure | Description | Time Frame |
|---|---|---|
| intrapulmonary shunt | blood sampling after induction of anesthesia, 15 and 30 min after OLV, after the 2nd TLV | participants will be followed for the duration of anesthesia, an expected average of 3 hours |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Yongseon Choi | Assistant professor | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Yong Seon Choi | Seoul | Seoul | South Korea |
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