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During general anesthesia surgery, the role of positive end-expiratory pressure (PEEP) in mechanical ventilation remains uncertain. Pressure levels above 0 cm Hâ‚‚O can prevent postoperative pulmonary complications but may also cause intraoperative circulatory depression and lung injury due to overdistension. Using very low levels of PEEP may lead to atelectasis. However, high levels of PEEP can not only trigger complications such as intraoperative circulatory depression but also promote hyperinflation. Positive end-expiratory pressure (PEEP) is required to prevent atelectasis during lung-protective ventilation, and different levels of PEEP exhibit varying physiological and clinical effects when used alone or in combination with alveolar recruitment maneuvers (ARM). Alveolar recruitment maneuvers (ARM) are used to open atelectatic lung parenchyma, but the duration of their benefits has not been clearly determined. This study aims to determine the effectiveness of different PEEP levels after ARM in general anesthesia surgery, the duration of their time-dependent responses, and their hemodynamic effects, providing a reference for how often recruitment maneuvers should be performed during general anesthesia and further refining the specific details of lung-protective ventilation strategies.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| A: PEEP=0 cmH2O | Placebo Comparator | Baseline respiratory mechanics parameters (driving pressure [DP], dynamic lung compliance [Cdyn]) and hemodynamic parameters (mean arterial pressure [MAP], SV, CO, CI) were recorded before ARM. Ten minutes after insufflation of the peritoneum with CO2 and positioning of the patient for surgery, an ARM was performed using the built-in protocol of the Mindray anesthesia machine, applying a continuous positive pressure of 30 cmH2O for 30 seconds. Immediately afterwards, the PEEP level was adjusted to 0 cmH2O. Respiratory and hemodynamic parameters were recorded at 5, 10, 15, 20, 25, 30, 35, and 40 minutes after ARM. The PEEP level was set back to 4 cmH2O forty minutes after ARM until the end of surgery. |
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| B: PEEP=4cmH2O | Experimental | Baseline respiratory mechanics parameters (driving pressure [DP], dynamic lung compliance [Cdyn]) and hemodynamic parameters (mean arterial pressure [MAP], SV, CO, CI) were recorded before ARM. Ten minutes after insufflation of the peritoneum with CO2 and positioning of the patient for surgery, an ARM was performed using the built-in protocol of the Mindray anesthesia machine, applying a continuous positive pressure of 30 cmH2O for 30 seconds. Immediately afterwards, the PEEP level was adjusted to 4 cmH2O. Respiratory and hemodynamic parameters were recorded at 5, 10, 15, 20, 25, 30, 35, and 40 minutes after ARM. The PEEP level was set back to 4 cmH2O forty minutes after ARM until the end of surgery. |
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| C: PEEP=8cmH2O | Experimental | Baseline respiratory mechanics parameters (driving pressure [DP], dynamic lung compliance [Cdyn]) and hemodynamic parameters (mean arterial pressure [MAP], SV, CO, CI) were recorded before ARM. Ten minutes after insufflation of the peritoneum with CO2 and positioning of the patient for surgery, an ARM was performed using the built-in protocol of the Mindray anesthesia machine, applying a continuous positive pressure of 30 cmH2O for 30 seconds. Immediately afterwards, the PEEP level was adjusted to 8 cmH2O. Respiratory and hemodynamic parameters were recorded at 5, 10, 15, 20, 25, 30, 35, and 40 minutes after ARM. The PEEP level was set back to 4 cmH2O forty minutes after ARM until the end of surgery. |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| lung recruitment maneuvre; PEEP | Behavioral | After the patient enters the operating room, routine monitoring of ECG, non-invasive blood pressure, and SpOâ‚‚ is performed. Local anesthesia is used for radial artery puncture and catheterization to monitor invasive blood pressure. After 3 minutes of pre-oxygenation, tracheal intubation is performed with the following ventilation parameters: VT 6-8 ml/kg, FiOâ‚‚ 60%, RR 15 breaths/min, I/E 1:2, and PEEP 4 cmHâ‚‚O. Ten minutes after the establishment of pneumoperitoneum during surgery, baseline levels of respiratory mechanical parameters and hemodynamic variables are recorded. Subsequently, alveolar recruitment is performed at a pressure of 30 cmHâ‚‚O for 30 seconds. Immediately after recruitment, the PEEP level is adjusted according to the group. The changes in respiratory mechanics parameters and hemodynamic variables after recruitment are recorded. After the outcome indicators recover to the new baseline level, the PEEP is readjusted to 4 cmHâ‚‚O. |
| Measure | Description | Time Frame |
|---|---|---|
| the duration of improvement in lung compliance | during the surgery |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Northern Jiangsu People's Hospital | Yangzhou | Jiangsu | China |
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| Type | Includes Protocol | Includes SAP | Includes ICF | Document Label | Document Date | Document Uploaded Date | Document File Name |
|---|---|---|---|---|---|---|---|
| Prot_SAP | Yes | Yes | No | Study Protocol and Statistical Analysis Plan | Nov 30, 2025 |
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| D: PEEP=12cmH2O | Experimental | Baseline respiratory mechanics parameters (driving pressure [DP], dynamic lung compliance [Cdyn]) and hemodynamic parameters (mean arterial pressure [MAP], SV, CO, CI) were recorded before ARM. Ten minutes after insufflation of the peritoneum with CO2 and positioning of the patient for surgery, an ARM was performed using the built-in protocol of the Mindray anesthesia machine, applying a continuous positive pressure of 30 cmH2O for 30 seconds. Immediately afterwards, the PEEP level was adjusted to 12 cmH2O. Respiratory and hemodynamic parameters were recorded at 5, 10, 15, 20, 25, 30, 35, and 40 minutes after ARM. The PEEP level was set back to 4 cmH2O forty minutes after ARM until the end of surgery. |
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| Mar 20, 2026 |
| Prot_SAP_000.pdf |
| ID | Term |
|---|---|
| D011175 | Positive-Pressure Respiration |
| ID | Term |
|---|---|
| D012121 | Respiration, Artificial |
| D058109 | Airway Management |
| D013812 | Therapeutics |
| D012138 | Respiratory Therapy |
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