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The increasing incidence of Alzheimer's disease (AD) and related sleep-disorders with the aging of the population is a major issue of public health. The prevalence of sleep disturbances is about 50% in dementia patients. Sleep in dementia is mainly characterized by prolonged night-time awakenings, sometimes with longer sleep latency and/or early awakening. The presence of these sleep disturbances is the main reason for the institutionalization of AD patients, as well as a major cause of the deterioration of the caregivers' sleep. The MEMENTO cohort is composed of patients with isolated memory complaints or mild cognitive impairment, at high risk to develop dementia. All voluntary patients from the CMRR (Center of Memory, resources and Research) of Bordeaux (MEMENTO cohort) will be tested at inclusion and followed-up 1 year later. For these two evaluations, actigraphic monitoring at home, 2-night polysomnography (PSG) monitoring at hospital including a 24-hour period of urinary melatonin dosage, neuropsychological tests battery, a virtual reality tool and questionnaires will be used.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Patients from Memento cohort. | Experimental | Patients with mild cognitive impairment included in MEMENTO cohort. These patients will have a 2 night polysomnography, a battery of neuropsychological tests, a virtual reality test, and a subjective evaluation of sleep and somnolence at inclusion (Month 0) and Month 12. |
|
| Patients with memory disorders | Experimental | Patients with mild cognitive impairment not included in MEMENTO cohort. For these patients a virtual reality test, and a subjective evaluation of sleep and somnolence will be performed at Inclusion (Month 0) |
|
| Healthy volunteers | Active Comparator | Healthy volunteers matched in age, sex and educational level with patients. For these volunteers a virtual reality test, and a subjective evaluation of sleep and somnolence will be performed at Inclusion (Month 0) |
|
| control group | Active Comparator | this group is composed with Healthy volunteers these volunteers will have a 2 night polysomnography, a battery of neuropsychological tests, a virtual reality test, and a subjective evaluation of sleep and somnolence at inclusion (Month 0) and Month 12. |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| 2 night polysomnography | Other | Polysomnography |
|
| Measure | Description | Time Frame |
|---|---|---|
| Polysomnography of night 1 | - Apnea/Hypopnea index, periodic limb movements index | Change from inclusion (Month 0) and Month 12 |
| Polysomnography of night 1 | - Excessive transient muscle activity, Sustained muscle activity | Change from inclusion (Month 0) and Month 12 |
| Polysomnography of night 1 | - Sleep structure parameters (% stage 1, 2, 3 and Rapid Eye movement, Delta activity, Spindle rate) | Change from inclusion (Month 0) and Month 12 |
| Polysomnography of night 1 | - Sleep duration parameters | Change from inclusion (Month 0) and Month 12 |
| Polysomnography of night 1 | - Sleep consolidation parameters | Change from inclusion (Month 0) and Month 12 |
| Polysomnography of night 1 | - Sleep propensity parameters 24-hour melatonin quantity rate | Change from inclusion (Month 0) and Month 12 |
| Polysomnography of night 1 | Actimetry: Inter-daily stability, intra-daily variability, rhythm amplitude | Change from inclusion (Month 0) and Month 12 |
| Measure | Description | Time Frame |
|---|---|---|
| Subjective evaluation of sleep and Somnolence | Month 0 and Month 12 | |
| Evaluation of Memory disorder | Reaction times and % of errors in the neuropsychological tests (memory, speed processing, language, visuo-spatial skills, attentional functions, executive functions) |
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Inclusion criteria for patients with mild cognitive impairment included in MEMENTO cohort:
Inclusion criteria for patients with mild cognitive impairment not included in MEMENTO cohort:
Inclusion criteria for Healthy volunteers and Control group:
Exclusion criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Pierre Philip, Pr | University Hospital, Bordeaux | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| CHU de Bordeaux | Bordeaux | 33076 | France |
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| ID | Term |
|---|---|
| D012893 | Sleep Wake Disorders |
| D060825 | Cognitive Dysfunction |
| D000077260 | Sleepiness |
| ID | Term |
|---|---|
| D009422 | Nervous System Diseases |
| D009461 | Neurologic Manifestations |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
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|
| battery of neuropsychological tests | Other |
|
| virtual reality test | Other |
|
| subjective evaluation of sleep and somnolence | Other |
|
| Month 0 and Month12 |
| Evaluation of Memory disorder | % of recall from the memory test in a virtual environment | Month 0 and Month12 |
| D001523 | Mental Disorders |
| D003072 | Cognition Disorders |
| D019965 | Neurocognitive Disorders |