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| ID | Type | Description | Link |
|---|---|---|---|
| 2012-A00625-38 | Other Identifier | ANSM |
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The main objective of this study is to determine a threshold value of diaphragmatic excursion (ultrasound measures: expiration versus inspiration)that best predicts a 50% collapsibility of the inferior vena cava.
Secondary objectives of this study are:
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Study population | Experimental | Healthy subjects with spontaneous ventilation, 18 to 50 years of age. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Ultrasounds with controlled breathing | Procedure | The patient will have cardiac, abdominal and thoracic ultrasounds with controlled and monitored inspiratory effort. This gesture takes about 40 minutes. |
| Measure | Description | Time Frame |
|---|---|---|
| Collapsibility score for the IVC diameter | percentage = ((max-min)/average)*100% Three variables are necessary to respond to the primary objective: (the collapsibility score for the IVC diameter; (2) whether or not this score is >= 50%; and (3) a measure of the diaphragmatic excursion. | Baseline (Day 0; cross-sectional study) |
| Collapsibility score for the IVC diameter >= 50% (presence/absence) | percentage = ((max-min)/average)*100% Three variables are necessary to respond to the primary objective: (the collapsibility score for the IVC diameter; (2) whether or not this score is >= 50%; and (3) a measure of the diaphragmatic excursion. | Baseline (Day 0; cross-sectional study) |
| Diaphragmatic excursion | Maximum distance between the position of the diaphragmatic dome during inspiration versus expiration (cm) Three variables are necessary to respond to the primary objective: (the collapsibility score for the IVC diameter; (2) whether or not this score is >= 50%; and (3) a measure of the diaphragmatic excursion. | Baseline (Day 0; cross-sectional study) |
| Measure | Description | Time Frame |
|---|---|---|
| Collapsibility score for the IVC diameter >= 40% (presence/absence) | percentage = ((max-min)/average)*100% | Baseline (Day 0; cross sectional study) |
| Collapsibility score for the IVC diameter >= 60% (presence/absence) |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Laurent Muller, MD | Centre Hospitalier Universitaire de Nīmes | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| CHU de Nîmes - Hôpital Universitaire Carémeau | Nîmes | 30029 | France |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 27003619 | Result | Gignon L, Roger C, Bastide S, Alonso S, Zieleskiewicz L, Quintard H, Zoric L, Bobbia X, Raux M, Leone M, Lefrant JY, Muller L. Influence of Diaphragmatic Motion on Inferior Vena Cava Diameter Respiratory Variations in Healthy Volunteers. Anesthesiology. 2016 Jun;124(6):1338-46. doi: 10.1097/ALN.0000000000001096. |
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| ID | Term |
|---|---|
| D019220 | High-Energy Shock Waves |
| ID | Term |
|---|---|
| D000069453 | Ultrasonic Waves |
| D013016 | Sound |
| D011840 | Radiation, Nonionizing |
| D011827 | Radiation |
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percentage = ((max-min)/average)*100%
| Baseline (Day 0; cross sectional study) |
| Mitral Doppler Wave E speed | cm/s | Baseline (Day 0; cross sectional study) |
| Mitral Doppler Wave A speed | cm/s | Baseline (Day 0; cross sectional study) |
| Tissue Doppler Wave E' speed | cm/s | Baseline (Day 0; cross sectional study) |
| Simpson: FEVG | % | Baseline (Day 0; cross sectional study) |
| D055585 |
| Physical Phenomena |