The Effect of Propofol Infusion on Total Antioxidant Status During Tourniquet-Induced Ischemia-Reperfusion Injury

The Effect of Propofol Infusion on Total Antioxidant Status During Tourniquet-Induced Ischemia-Reperfusion Injury in Total Knee Arthroplasty

The release of tourniquet produces reactive oxygen species which can cause injury. Propofol is chemically similar to phenol-based free radical scavengers.

Plasma total antioxidant capacity is a well-established marker of the overall protective effect of antioxidants in body fluids.The aim of the study is to investigate the effects of propofol on ischemia-reperfusion injury in total knee arthroplasty (TKA).

Inclusion Criteria:

• ASA I-II physical status
• Unilateral total knee arthroplasty
• Age 18 years to 80 years

Exclusion Criteria:

• Severe central nervous system disorders
• Severe cardiopulmonary,renal,metabolic, or hepatic disease,
• Blood volume deficits,
• Coagulopathy,
• Allergy to local anesthetics,
• Peripheral neuropathies,
• Body mass index > 35,
• History of antioxidant drug use