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The release of tourniquet produces reactive oxygen species which can cause injury. Propofol is chemically similar to phenol-based free radical scavengers.
Plasma total antioxidant capacity is a well-established marker of the overall protective effect of antioxidants in body fluids.The aim of the study is to investigate the effects of propofol on ischemia-reperfusion injury in total knee arthroplasty (TKA).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Propofol | Active Comparator | Propofol infusion group: Under spinal anesthesia, a continuous intravenous infusion (2mg/kg/h) of propofol will be use during the operation |
|
| Control group | Placebo Comparator | Placebo group: Under spinal anesthesia, a continuous intravenous infusion of volume-equivalent placebo will use during the operation |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Propofol | Drug | Propofol :Propofol is an anesthetic agent, has structure similar to that of known such as alfa tocopherol. |
|
| Measure | Description | Time Frame |
|---|---|---|
| The perioperative alternation of the venous blood total antioxidant capacity levels of the arms | T1 : Before the spinal anesthesia performed T2 : At 30th min of tourniquet inflation T3 : At 2nd hours of tourniquet deflation | T1,T2,T3 |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Derya Özkan, MD | Ministry of health Diskapi Yıldirim Beyazit Training and Research Hospital Anesthesiology Clinic | Principal Investigator |
| Taylan Akkaya, MD | Ministry of health Diskapi Yıldirim Beyazit Training and Research Hospital Anesthesiology Clinic | Study Chair |
| Ali Yalcindag, MD | Ministry of health Diskapi Yıldirim Beyazit Training and Research Hospital Biochemistry Clinic | Study Chair |
| Tuba Hanci, MD | Ministry of health Diskapi Yıldirim Beyazit Training and Research Hospital Biochemistry Clinic | Study Chair |
| Haluk Gümüs, MD | Ministry of health Diskapi Yıldirim Beyazit Training and Research Hospital Anesthesiology Clinic | Study Chair |
| Namik Delibas, MD | Ministry of health Diskapi Yıldirim Beyazit Training and Research Hospital Biochemistry Clinic | Study Chair |
| Emel Gönen, Consultant | Ministry of health Diskapi Yıldirim Beyazit Training and Research Hospital Orthopedics Clinic | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Ministry of health Diskapi Yıldirim Beyazit Training and Research Hospital Anesthesiology and Biochemistry Clinics | Ankara | 06110 | Turkey (Türkiye) |
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| Placebo | Drug |
|
| ID | Term |
|---|---|
| D015742 | Propofol |
| ID | Term |
|---|---|
| D010636 | Phenols |
| D001555 | Benzene Derivatives |
| D006841 | Hydrocarbons, Aromatic |
| D006844 | Hydrocarbons, Cyclic |
| D006838 | Hydrocarbons |
| D009930 | Organic Chemicals |
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