This is a multi-center, prospective, non-interventional study of patients who have been diagnosed with moderate to severe symptoms of uterine fibroids and are initiating a pre-operative treatment with ESMYA.

The objectives of the study are to characterize and describe treatment with ESMYA and to evaluate the safety, effectiveness, and HRQL outcomes in this population

Inclusion Criteria:

- Pre-menopausal adult women with a diagnosis of moderate or severe symptoms of uterine fibroids who are initiating treatment with ESMYA.

Exclusion Criteria:

• Patient is pregnant or plans to become pregnant in the next 3 months,
• Patient is breastfeeding,
• Patient has genital bleeding of unknown etiology or not due to uterine fibroids,
• Patient has been diagnosed with uterine, cervical, ovarian or breast cancer,
• Patient is using an investigational drug/therapy or has discontinued the use of an investigational drug/therapy within 30 days prior to study enrollment,
• Patient has hypersensitivity to the active substance of ESMYA or to one of its excipients

The target study population will include women who have had a diagnosis of symptomatic uterine fibroids and are initiating preoperative treatment with ESMYA.