The Effect of Topical Application of Tranexamic Acid in Total Hip Arthroplasty Through the Direct Anterior Approach

The Effect of Topical Application of Tranexamic Acid in Total Hip Arthroplasty Through the Direct Anterior Approach. A Prospective, Double Blind, Placebo-controlled Clinical Trial.

The effects of topical application of 3g tranexamic acid for 2 hours prior to opening of the suction drain following a total hip replacement

Inclusion Criteria:

• patients who will receive a unilateral total hip arthroplasty

Exclusion Criteria:

• coagulopathy
• allergy to tranexamic acid
• preoperative anemia (a hemoglobin value of < 11g/dL in females and < 12g/dL in males)
• fibrinolytic disorders
• a history of arterial or venous thromboembolic disease
• pregnancy
• breastfeeding
• major comorbidities