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Tranexamic acid has been shown to reduce postoperative blood losses and transfusion requirements in a number of types of surgery. Most trials in orthopedic surgery have been conducted intravenously in arthroplasty, hip fracture and spine surgeries. This study would aim to see the effect of topical use of tranexamic acid in reduction of blood loss and transfusions for total hip arthroplasty
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Tranexamic Acid | Experimental |
| |
| control group | Placebo Comparator |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Tranexamic Acid | Drug | 1 g Tranexamic Acid mixed with 100ml saline are kept in wound for 2 hours before drainage is opened postoperatively |
|
| Measure | Description | Time Frame |
|---|---|---|
| Blood loss as calculated from change in haematocrit | 7 days |
| Measure | Description | Time Frame |
|---|---|---|
| Intra-operative blood loss | 1 day | |
| Postoperative blood loss | postoperative 4 hours, 1 day, 2 days, 7days respectively | |
| Hemoglobin levels |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Yong Li | The First Affiliated Hospital, Guangzhou University of Traditional Chinese Medicine | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| the First Affiliated Hospital of Guangzhou TCM University | Recruiting | Guangzhou | Guangdong | 510405 | China |
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| ID | Term |
|---|---|
| D019106 | Postoperative Hemorrhage |
| ID | Term |
|---|---|
| D006470 | Hemorrhage |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D011183 | Postoperative Complications |
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| ID | Term |
|---|---|
| D014148 | Tranexamic Acid |
| D000077330 | Saline Solution |
| ID | Term |
|---|---|
| D003509 | Cyclohexanecarboxylic Acids |
| D000146 | Acids, Carbocyclic |
| D002264 | Carboxylic Acids |
| D009930 | Organic Chemicals |
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| normal saline | Drug | 100ml saline is kept in wound for 2 hours before drainage is opened postoperatively |
|
| postoperative 4 hours, 1 day, 2 days, 7days respectively |
| drainage volume | postoperative 1 day, 2 days |
| Proportion of patients receiving transfusions | 7 days |
| Incidence of deep vein thrombosis postoperatively | 7 days |
| D000077324 |
| Crystalloid Solutions |
| D007552 | Isotonic Solutions |
| D012996 | Solutions |
| D004364 | Pharmaceutical Preparations |