Aspirin for the Enhancement of Trophoblastic Invasion in Women With Abnormal Uterine Artery Doppler at 11-14 Weeks of Gestation

Aspirin for the Enhancement of Trophoblastic Invasion in Women With Abnormal Uterine Artery Doppler at 11-14 Weeks of Gestation

To establish wether a prophylactic intervention from first trimester with low-dose of aspirin improves trophoblastic invasion evaluated at third trimester in women defined as high-risk by abnormal uterine artery Doppler at first trimester

Inclusion Criteria:

• Patients over 18 years old attending for routine ultrasound at first trimester of pregnancy between 11 and 14 weeks of gestation (Crown-to rump length 45-48mm)
• Single gestation
• Mean pulsatility index of the uterine arteries above the 95th percentile for our population

Exclusion Criteria:

• Pre-existing hypertension, renal or cardiovascular disease
• previous history of pre-eclampsia
• Pregestational diabetes
• Systemic lupus Erythematosus
• Gastric ulcer
• Acetylsalicylic acid or lactose hypersensitivity
• Bleeding disorders
• Fetal disorders (including chromosomal abnormalities)
• Administration of low molecular weight heparin
• Concomitant treatment with aspirin