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| Name | Class |
|---|---|
| Thomas Jefferson University | OTHER |
| Jawaharlal Nehru Medical College | OTHER |
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Available data suggest that low dose aspirin may be a safe, widely available and inexpensive intervention that may significantly reduce the risk of preterm birth. However, this possibility needs to be proven in a properly designed randomized controlled trial (RCT) with preterm birth as the primary outcome. Such a clinical trial in a racially, ethnically and geographically diverse population could best be accomplished by the established infrastructure of the Global Network for Women's and Children's Health Research (GN).
Background: Preterm birth (PTB) remains the leading cause of neonatal mortality and long term disability throughout the developed and developing world. Though complex in its origins, a growing body of evidence suggests that first trimester administration of low dose aspirin (LDA) holds promise to reduce the rate of PTB substantially.
Hypothesis: The investigators' primary hypothesis is that nulliparous women with no more than two previous first trimester pregnancy losses who are treated with LDA daily beginning between 6 0/7 weeks and 13 6/7 weeks gestational age (GA) through 36 0/7 weeks GA will reduce the risk of preterm birth from all causes.
Study Design Type: Prospective randomized, placebo-controlled, double-blinded multicenter clinical trial (patient level 1:1).
Population: Nulliparous women between the ages of 18 (or local age of majority) and 40 with no more than two previous first trimester pregnancy losses or any second trimester spontaneous pregnancy loss, a singleton pregnancy between 6 0/7 weeks and 13 6/7 weeks GA confirmed by ultrasound, and no contraindications to aspirin. Other medical conditions, such as sickle-cell anemia, may be considered a contraindication per the judgment of the site investigator.
Intervention: Daily administration of low dose (81 mg) aspirin [also known as acetylsalicylic acid (ASA)], initiated between 6 0/7 weeks and 13 6/7 weeks GA and continued to 36 0/7 weeks GA compared to an identical appearing placebo. Compliance and outcomes will be assessed biweekly.
Outcomes:
The primary outcome is to determine whether daily LDA initiated between 6 0/7 weeks and 13 6/7 weeks and continued to 36 0/7 weeks reduces the risk of preterm birth (birth prior to 37 0/7 weeks of pregnancy) by 20%. This will be determined based on assessed date of delivery in comparison to the projected estimated date of delivery, independent of whether or not the preterm delivery is indicated or spontaneous.
Secondary outcomes include:
Other secondary outcomes of interest are:
Maternal outcomes:
Fetal outcomes:
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Intervention Arm | Active Comparator | Women will be randomized equally to receive daily low dose aspirin (LDA) [also known as acetylsalicylic acid (ASA)] of 81 mg beginning between 6 0/7 weeks and 13 6/7 weeks GA and continuing until 36 0/7 weeks GA or delivery. |
|
| Placebo Arm | Placebo Comparator | Women will be randomized equally to receive an identical appearing placebo beginning between 6 0/7 weeks and 13 6/7 weeks GA and continuing until 36 0/7 weeks GA or delivery. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Low dose aspirin | Drug | Daily administration of low dose (81 mg) aspirin [also known as acetylsalicylic acid (ASA], initiated between 6 0/7 weeks and 13 6/7 weeks GA and continued to 36 0/7 weeks GA compared to an identical appearing placebo. Compliance and outcomes will be assessed biweekly. |
| Measure | Description | Time Frame |
|---|---|---|
| Incidence of Preterm Birth | The primary outcome of this study is incidence of preterm birth, which will be defined as delivery at or after 20 0/7 weeks and prior to 37 0/7 weeks. This will be determined based on actual date of delivery in comparison to the projected estimated due date (EDD), independent of whether or not the preterm delivery is indicated or spontaneous. | At delivery |
| Measure | Description | Time Frame |
|---|---|---|
| Incidence of Hypertensive Disorders of Pregnancy | - Hypertensive disorders of pregnancy is defined by the characterization of evidence of a hypertensive disorder, including either preeclampsia or eclampsia occurring during the pregnancy. | Evidence of hypertensive disorder during the pregnancy (prior to delivery/birth) |
| Measure | Description | Time Frame |
|---|---|---|
| Maternal Outcome 1 - Incidence of Vaginal Bleeding | - Vaginal bleeding | At delivery or at Day 42 after delivery |
| Maternal Outcome 2 - Incidence of Antepartum Hemorrhage | - Antepartum hemorrhage |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Marion Koso-Thomas, MD | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Alabama, Birmingham | Birmingham | Alabama | 35233 | United States | ||
| University of Colorado, Denver |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 22370109 | Background | Abramovici A, Cantu J, Jenkins SM. Tocolytic therapy for acute preterm labor. Obstet Gynecol Clin North Am. 2012 Mar;39(1):77-87. doi: 10.1016/j.ogc.2011.12.003. Epub 2012 Jan 4. | |
| 15863548 | Background | Ananth CV, Joseph KS, Oyelese Y, Demissie K, Vintzileos AM. Trends in preterm birth and perinatal mortality among singletons: United States, 1989 through 2000. Obstet Gynecol. 2005 May;105(5 Pt 1):1084-91. doi: 10.1097/01.AOG.0000158124.96300.c7. |
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Participants were randomly assigned (1:1, stratified by site) to receive aspirin or placebo tablets of identical appearance, via a sequence generated centrally by the data coordinating center.
Randomized, multi-country, double-masked, placebo-controlled trial of low-dose aspirin (81 mg daily) initiated between 6 weeks and 0 days of pregnancy, and 13 weeks and 6 days of pregnancy, in nulliparous women with an ultrasound confirming gestational age and a singleton viable pregnancy.
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| ID | Title | Description |
|---|---|---|
| FG000 | Intervention Arm | Daily administration of low dose (81 mg) aspirin [also known as acetylsalicylic acid (ASA], initiated between 6 0/7 weeks and 13 6/7 weeks GA and continued to 36 0/7 weeks GA. |
| FG001 | Placebo Arm |
| Title | Milestones | Reasons Not Completed | |||||
|---|---|---|---|---|---|---|---|
| Overall Study |
|
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| Type | Includes Protocol | Includes SAP | Includes ICF | Document Label | Document Date | Document Uploaded Date | Document File Name |
|---|---|---|---|---|---|---|---|
| Prot_SAP | Yes | Yes | No | Study Protocol and Statistical Analysis Plan | Feb 21, 2019 |
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|
| Placebo | Drug | Placebo |
|
| Incidence of Small for Gestational Age (SGA) |
- Small for gestational age (SGA) as defined by the INTERGROWTH-21st standard |
| At delivery or at Day 42 after delivery |
| Incidence of Perinatal Mortality | - Incidence of Perinatal Mortality | At delivery or at Day 42 after delivery |
| At delivery or at Day 42 after delivery |
| Maternal Outcome 3 - Incidence of Postpartum Hemorrhage | - Postpartum hemorrhage | At delivery or at Day 42 after delivery |
| Maternal Outcome 4 - Incidence of Maternal Mortality | - Incidence of Maternal Mortality | At delivery or at Day 42 after delivery |
| Maternal Outcome 5 - Incidence of Late Abortion | - Incidence of Late Abortion | At delivery or at Day 42 after delivery |
| Maternal Outcome 6 - Change in Maternal Hemoglobin | Hemoglobin < 7.0 gm/dl at 26-30 weeks gestation or a drop of 3.5+ gm/dl from screening to 26-30 weeks gestation | At enrollment, 4 weeks post enrollment, and 26-30 weeks GA. |
| Maternal Outcome 7 - Incidence of Preterm, Preeclampsia | Early preterm delivery (<34 weeks) and hypertensive disorders (i.e.: preeclampsia) | At delivery or at Day 42 after delivery |
| Fetal Outcome 1 - Incidence of Early Preterm Delivery (<34 Weeks) | - Early preterm delivery (<34 weeks) | At delivery |
| Fetal Outcome 2 - Incidence of Actual Birth Weight <2500g | - Birth weight <2500g | At delivery |
| Fetal Outcome 3 - Incidence of Actual Birth Weight <1500g | - Birth weight <1500g | At delivery |
| Fetal Outcome 4 - Incidence of Fetal Loss | - Incidence of Fetal Loss | At delivery |
| Fetal Outcome 5 - Incidence of Spontaneous Abortion | - Incidence of Spontaneous Abortion | At delivery |
| Fetal Outcome 6 - Incidence of All Stillbirth | - Incidence of All stillbirth | At delivery |
| Fetal Outcome 7 - Incidence of Medical Termination of Pregnancy | - Incidence of Medical Termination of Pregnancy | At delivery |
| Denver |
| Colorado |
| 80045 |
| United States |
| Indiana University | Indianapolis | Indiana | 46202 | United States |
| Boston University | Boston | Massachusetts | 02215 | United States |
| Columbia University | New York | New York | 10032 | United States |
| University of North Carolina, Chapel Hill | Chapel Hill | North Carolina | 27599 | United States |
| Thomas Jefferson University | Philadelphia | Pennsylvania | 19107 | United States |
| Kinshasa School of Public Health | Kinshasa | Democratic Republic of the Congo |
| Institute of Nutrition of Central America and Panama (INCAP) | Guatemala City | 01015 | Guatemala |
| KLE University's Jawaharlal Nehru Medical College | Belagavi | Karnataka | India |
| Lata Medical Research Foundation | Nagpur | India |
| Moi University School of Medicine | Eldoret | 30100 | Kenya |
| The Aga Khan University | Karachi | 74800 | Pakistan |
| University Teaching Hospital | Lusaka | Zambia |
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| 42090150 | Derived | Meltzer GY, Duttweiler LP, Saleem S, Shankar K, Mazariegos M, Tshefu A, Patterson JK, Chomba E, Carlo WA, Goudar S, Derman R, Patel AB, Hibberd PL, Liechty E, Essamai F, Asturias E, Babineau DC, Moore J, Tuholske C, Zimmer A, Coull BA, McClure E, Goldenberg RL, Krebs N, Hoffman MK, Wylie BJ. Aspirin and Preterm Birth Among Pregnant People With Increased Heat Exposure: Secondary Analysis of a Randomized Clinical Trial. JAMA Netw Open. 2026 May 1;9(5):e2611402. doi: 10.1001/jamanetworkopen.2026.11402. |
| 42002305 | Derived | Mwenechanya M, Tembo AM, Chomba E, Hoffman MK, Goudar SS, Moore JL, Metgud MC, Somannavar MS, Okitawutshu J, Lokangaka AL, Tshefu AK, Bose CL, Bauserman MS, Figueroa L, Garces A, Krebs NF, Jessani S, Saleem S, Goldenberg RL, Kurhe K, Das P, Patel AB, Hibberd PL, Nyongesa P, Esamai F, Bucher SL, Goco N, Hemingway-Foday JJ, Babineau DC, McClure EM, Silver RM, Derman RJ, Carlo WA; ASPIRIN Study Group Collaborators. Does Adherence Modify Low-Dose Aspirin Effects in Pregnancy? Post Hoc Analysis From a Multi-Centre Trial. BJOG. 2026 Apr 19. doi: 10.1111/1471-0528.70244. Online ahead of print. |
| 36890485 | Derived | Bucher S, Nowak K, Otieno K, Tenge C, Marete I, Rutto F, Kemboi M, Achieng E, Ekhaguere OA, Nyongesa P, Esamai FO, Liechty EA. Birth weight and gestational age distributions in a rural Kenyan population. BMC Pediatr. 2023 Mar 8;23(1):112. doi: 10.1186/s12887-023-03925-2. |
| 31982074 | Derived | Hoffman MK, Goudar SS, Kodkany BS, Metgud M, Somannavar M, Okitawutshu J, Lokangaka A, Tshefu A, Bose CL, Mwapule A, Mwenechanya M, Chomba E, Carlo WA, Chicuy J, Figueroa L, Garces A, Krebs NF, Jessani S, Zehra F, Saleem S, Goldenberg RL, Kurhe K, Das P, Patel A, Hibberd PL, Achieng E, Nyongesa P, Esamai F, Liechty EA, Goco N, Hemingway-Foday J, Moore J, Nolen TL, McClure EM, Koso-Thomas M, Miodovnik M, Silver R, Derman RJ; ASPIRIN Study Group. Low-dose aspirin for the prevention of preterm delivery in nulliparous women with a singleton pregnancy (ASPIRIN): a randomised, double-blind, placebo-controlled trial. Lancet. 2020 Jan 25;395(10220):285-293. doi: 10.1016/S0140-6736(19)32973-3. |
| 28468653 | Derived | Hoffman MK, Goudar SS, Kodkany BS, Goco N, Koso-Thomas M, Miodovnik M, McClure EM, Wallace DD, Hemingway-Foday JJ, Tshefu A, Lokangaka A, Bose CL, Chomba E, Mwenechanya M, Carlo WA, Garces A, Krebs NF, Hambidge KM, Saleem S, Goldenberg RL, Patel A, Hibberd PL, Esamai F, Liechty EA, Silver R, Derman RJ. A description of the methods of the aspirin supplementation for pregnancy indicated risk reduction in nulliparas (ASPIRIN) study. BMC Pregnancy Childbirth. 2017 May 3;17(1):135. doi: 10.1186/s12884-017-1312-x. |
Identical appearing placebo beginning between 6 0/7 weeks and 13 6/7 weeks GA and continuing until 36 0/7 weeks GA or delivery.
| Treated |
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| Included in mITT Analysis | A modified intention-to-treat (mITT) analysis was planned a priori for the primary and secondary outcomes to include only women who delivered at or after 20 weeks and were determined to be eligible after randomization. Numbers reported in the Outcomes section reflect available data and therefore do not always reflect the total population defined in the mITT. |
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| COMPLETED |
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| NOT COMPLETED |
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Women who were eligible according to the modified intention-to-treat (mITT) criteria and included in the mITT analysis.
Not provided
| ID | Title | Description |
|---|---|---|
| BG000 | Intervention Arm | Daily administration of low dose (81 mg) aspirin [also known as acetylsalicylic acid (ASA], initiated between 6 0/7 weeks and 13 6/7 weeks GA and continued to 36 0/7 weeks GA. |
| BG001 | Placebo Arm | Identical appearing placebo beginning between 6 0/7 weeks and 13 6/7 weeks GA and continuing until 36 0/7 weeks GA or delivery. |
| BG002 | Total | Total of all reporting groups |
| Units | Counts |
|---|---|
| Participants |
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| Title | Description | Population Description | Parameter Type | Dispersion Type | Unit of Measure | Calculate Percentage | Denominator Units Selected | Denominators | Classes | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Age, Customized | Count of Participants | Participants |
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| Sex: Female, Male | Count of Participants | Participants |
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| Race and Ethnicity Not Collected | Race and Ethnicity were not collected from any participant. | Count of Participants | Participants |
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| Maternal Education | Count of Participants | Participants |
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| Number of pregnancies | Count of Participants | Participants |
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| Projected gestational age at enrollment | Median | Inter-Quartile Range | weeks |
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| Maternal Height | Mean | Standard Deviation | cm |
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| Maternal Weight | Mean | Standard Deviation | kg |
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| Maternal body-mass-index | Mean | Standard Deviation | kg/m^2 |
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| Antenatal care visits | Median | Inter-Quartile Range | visits |
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| Delivery attendant | Count of Participants | Participants |
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| Delivery mode | Count of Participants | Participants |
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| Delivery location | Count of Participants | Participants |
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| Site | Count of Participants | Participants |
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| Type | Title | Description | Population Description | Reporting Status | Anticipated Posting Date | Parameter Type | Dispersion Type | Unit of Measure | Calculate Percentage | Time Frame | Units Analyzed | Denominator Units Selected | Arm/Group Information | Denominators | Classes | Analyses | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Primary | Incidence of Preterm Birth | The primary outcome of this study is incidence of preterm birth, which will be defined as delivery at or after 20 0/7 weeks and prior to 37 0/7 weeks. This will be determined based on actual date of delivery in comparison to the projected estimated due date (EDD), independent of whether or not the preterm delivery is indicated or spontaneous. | Modified ITT; numbers reported reflect available data and therefore do not always reflect the total population defined in the mITT | Posted | Count of Participants | Participants | At delivery |
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| Secondary | Incidence of Hypertensive Disorders of Pregnancy | - Hypertensive disorders of pregnancy is defined by the characterization of evidence of a hypertensive disorder, including either preeclampsia or eclampsia occurring during the pregnancy. | Modified ITT; numbers reported reflect available data and therefore do not always reflect the total population defined in the mITT | Posted | Count of Participants | Participants | Evidence of hypertensive disorder during the pregnancy (prior to delivery/birth) |
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| Secondary | Incidence of Small for Gestational Age (SGA) | - Small for gestational age (SGA) as defined by the INTERGROWTH-21st standard | Modified ITT; numbers reported reflect available data and therefore do not always reflect the total population defined in the mITT | Posted | Count of Participants | Participants | At delivery or at Day 42 after delivery |
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| Secondary | Incidence of Perinatal Mortality | - Incidence of Perinatal Mortality | Modified ITT; numbers reported reflect available data and therefore do not always reflect the total population defined in the mITT | Posted | Count of Participants | Participants | No | At delivery or at Day 42 after delivery |
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| Other Pre-specified | Maternal Outcome 1 - Incidence of Vaginal Bleeding | - Vaginal bleeding | ITT population; numbers reported reflect available data and therefore do not always reflect the total population defined in the ITT | Posted | Count of Participants | Participants | At delivery or at Day 42 after delivery |
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| Other Pre-specified | Maternal Outcome 2 - Incidence of Antepartum Hemorrhage | - Antepartum hemorrhage | Modified ITT; numbers reported reflect available data and therefore do not always reflect the total population defined in the mITT | Posted | Count of Participants | Participants | At delivery or at Day 42 after delivery |
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| Other Pre-specified | Maternal Outcome 3 - Incidence of Postpartum Hemorrhage | - Postpartum hemorrhage | Safety population (women receiving at least one dose of drug or placebo); numbers reported reflect available data | Posted | Count of Participants | Participants | At delivery or at Day 42 after delivery |
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| Other Pre-specified | Maternal Outcome 4 - Incidence of Maternal Mortality | - Incidence of Maternal Mortality | ITT population; numbers reported reflect available data and therefore do not always reflect the total population defined in the ITT | Posted | Count of Participants | Participants | No | At delivery or at Day 42 after delivery |
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| Other Pre-specified | Maternal Outcome 5 - Incidence of Late Abortion | - Incidence of Late Abortion | ITT population; numbers reported reflect available data and therefore do not always reflect the total population defined in the ITT | Posted | Count of Participants | Participants | No | At delivery or at Day 42 after delivery |
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| Other Pre-specified | Maternal Outcome 6 - Change in Maternal Hemoglobin | Hemoglobin < 7.0 gm/dl at 26-30 weeks gestation or a drop of 3.5+ gm/dl from screening to 26-30 weeks gestation | Posted | Count of Participants | Participants | At enrollment, 4 weeks post enrollment, and 26-30 weeks GA. |
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| Other Pre-specified | Maternal Outcome 7 - Incidence of Preterm, Preeclampsia | Early preterm delivery (<34 weeks) and hypertensive disorders (i.e.: preeclampsia) | Modified ITT; numbers reported reflect available data and therefore do not always reflect the total population defined in the mITT | Posted | Count of Participants | Participants | At delivery or at Day 42 after delivery |
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| Other Pre-specified | Fetal Outcome 1 - Incidence of Early Preterm Delivery (<34 Weeks) | - Early preterm delivery (<34 weeks) | Modified ITT; numbers reported reflect available data and therefore do not always reflect the total population defined in the mITT | Posted | Count of Participants | Participants | At delivery |
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| Other Pre-specified | Fetal Outcome 2 - Incidence of Actual Birth Weight <2500g | - Birth weight <2500g | Modified ITT; numbers reported reflect available data and therefore do not always reflect the total population defined in the mITT | Posted | Count of Participants | Participants | At delivery |
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| Other Pre-specified | Fetal Outcome 3 - Incidence of Actual Birth Weight <1500g | - Birth weight <1500g | Modified ITT; numbers reported reflect available data and therefore do not always reflect the total population defined in the mITT | Posted | Count of Participants | Participants | At delivery |
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| Other Pre-specified | Fetal Outcome 4 - Incidence of Fetal Loss | - Incidence of Fetal Loss | ITT population; numbers reported reflect available data and therefore do not always reflect the total population defined in the ITT | Posted | Count of Participants | Participants | At delivery |
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| Other Pre-specified | Fetal Outcome 5 - Incidence of Spontaneous Abortion | - Incidence of Spontaneous Abortion | ITT population; numbers reported reflect available data and therefore do not always reflect the total population defined in the ITT | Posted | Count of Participants | Participants | No | At delivery |
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| Other Pre-specified | Fetal Outcome 6 - Incidence of All Stillbirth | - Incidence of All stillbirth | Modified ITT; numbers reported reflect available data and therefore do not always reflect the total population defined in the mITT | Posted | Count of Participants | Participants | No | At delivery |
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| Other Pre-specified | Fetal Outcome 7 - Incidence of Medical Termination of Pregnancy | - Incidence of Medical Termination of Pregnancy | ITT population; numbers reported reflect available data and therefore do not always reflect the total population defined in the ITT | Posted | Count of Participants | Participants | No | At delivery |
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Adverse events were monitored continuously throughout the study (from enrollment through 6-weeks post delivery) and recorded every 2-weeks.
SAEs were monitored for any event that: resulted in maternal or fetal death; was life-threatening; required hospitalization; resulted in persistent or significant disability; or any other serious or unexpected AE that the investigators felt should be reported. Specific AEs to be monitored included maternal death, upper GI bleeding, fetal anomaly, gastroschisis, post-partum hemorrhage, or antepartum hemorrhage. Other [Not Including Serious] AEs were not monitored/assessed.
Not provided
| ID | Title | Description | Deaths (Affected) | Deaths (At Risk) | Serious Events (Affected) | Serious Events (At Risk) | Other Events (Affected) | Other Events (At Risk) |
|---|---|---|---|---|---|---|---|---|
| EG000 | Intervention Arm | Daily administration of low dose (81 mg) aspirin [also known as acetylsalicylic acid (ASA], initiated between 6 0/7 weeks and 13 6/7 weeks GA and continued to 36 0/7 weeks GA. | 9 | 5,943 | 832 | 5,943 | 0 | 0 |
| EG001 | Placebo Arm | Identical appearing placebo beginning between 6 0/7 weeks and 13 6/7 weeks GA and continuing until 36 0/7 weeks GA or delivery. | 12 | 5,936 | 857 | 5,936 | 0 | 0 |
| Term | Organ System | Source Vocabulary | Assessment Type | Notes | Statistical Information |
|---|---|---|---|---|---|
| Maternal death | Pregnancy, puerperium and perinatal conditions | Systematic Assessment |
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| Fetal loss | Pregnancy, puerperium and perinatal conditions | Systematic Assessment |
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| Neonatal death up to 28 days | Pregnancy, puerperium and perinatal conditions | Systematic Assessment |
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| Miscarriage, abortion, or medical termination of pregnancy | Pregnancy, puerperium and perinatal conditions | Systematic Assessment |
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| Preterm labour or preterm birth evaluation before delivery | Pregnancy, puerperium and perinatal conditions | Systematic Assessment |
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| Antepartum haemorrhage | Pregnancy, puerperium and perinatal conditions | Systematic Assessment |
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| Post-partum harmorrhage | Pregnancy, puerperium and perinatal conditions | Systematic Assessment |
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| Vaginal spotting, bleeding, or leaking | Reproductive system and breast disorders | Systematic Assessment |
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| Congenital anomaly | Congenital, familial and genetic disorders | Systematic Assessment |
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| Anaemia | Blood and lymphatic system disorders | Systematic Assessment |
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| Fever or infection | Infections and infestations | Systematic Assessment |
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| Other | Pregnancy, puerperium and perinatal conditions | Systematic Assessment |
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| Upper gastrointestinal bleeding | Gastrointestinal disorders | Systematic Assessment |
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| Pre-eclampsia or eclampsia | Pregnancy, puerperium and perinatal conditions | Systematic Assessment |
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| Hypertension admission or medical visit before delivery | Cardiac disorders | Systematic Assessment |
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Not provided
Not provided
Not provided
| Title | Organization | Phone | Extension | |
|---|---|---|---|---|
| Elizabeth McClure | RTI International | 919-316-3773 | mcclure@rti.org |
| Jan 8, 2021 |
| Prot_SAP_000.pdf |
| ID | Term |
|---|---|
| D047928 | Premature Birth |
| ID | Term |
|---|---|
| D007752 | Obstetric Labor, Premature |
| D007744 | Obstetric Labor Complications |
| D011248 | Pregnancy Complications |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
Not provided
Not provided
| ID | Term |
|---|---|
| D001241 | Aspirin |
| ID | Term |
|---|---|
| D012459 | Salicylates |
| D062385 | Hydroxybenzoates |
| D010636 | Phenols |
| D001555 | Benzene Derivatives |
| D006841 | Hydrocarbons, Aromatic |
| D006844 | Hydrocarbons, Cyclic |
| D006838 | Hydrocarbons |
| D009930 | Organic Chemicals |
Not provided
Not provided
| 20-29 years |
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| >29 years |
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