Randomized Study of Letrozole and Trilostane for Medical Abortion

A Randomized Pilot Study of Two New Drug Combinations Fot the Termination fo Early Pregnancy

In menstruation an effective shedding of the endometrial lining occurs. Both progesterone and estrogen levels fall sharply at this time. During medical abortion the endometrial shedding is sometimes ineffective causing an incomplete abortion which may cause prolonged bleeding or require surgical intervention. In medical abortion a progesterone antagonist is used as treatment but the estrogen levels are not targeted. The investigators wish to explore whether addition of letrozole or trilostane which target estrogen levels can lead to a more effective shedding of the endometrial lining.

Inclusion Criteria:

• Healthy women aged 18-45 without any contraindication for treatment of any of the drugs involved in teh study

Exclusion Criteria:

• Any ongoing medication or medical condition smoking >20 cigarettes per day BMI >30