Letrozole and Misoprostol for Termination of Pregnancy up to 63 Days' Gestation

Letrozole and Misoprostol for Termination of Pregnancy up to 63 Days' Gestation: A Pilot Study to Evaluate the Safety and Acceptably of a User-friendly Regimen

Study to determine if a user-friendly medical abortion regimen using letrozole and misoprostol is safe and acceptable.

Inclusion Criteria:

• Pregnancy ≤ 63 days gestational age by ultrasound seeking termination of pregnancy
• Pregnancy visible on ultrasound
• Speaks English or Spanish
• Willing and able to return for follow-up appointment

Exclusion Criteria:

• People with gestations > 63 days gestational age
• Confirmed or suspected ectopic pregnancy or undiagnosed adnexal mass
• Pregnancy of unknown location
• IUD or contraceptive implant in place
• History of allergy to letrozole or misoprostol
• Unable to return for clinic-based follow-up
• Currently breastfeeding
• Twin or multiple pregnancy
• History of liver disease or abnormal liver function