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| Name | Class |
|---|---|
| Cargill | INDUSTRY |
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The study will determine whether acute and chronic consumption of a beverage containing erythritol will improve endothelial function in patients with type 2 diabetes mellitus.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Erythritol-containing beverage | Experimental |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Erythritol-containing beverage | Dietary Supplement | Orange flavored beverage containing erythritol |
|
| Measure | Description | Time Frame |
|---|---|---|
| Brachial artery flow mediated dilation | Change from baseline at 28 days |
| Measure | Description | Time Frame |
|---|---|---|
| Brachial artery flow-mediated dilation | Reactive hyperemia, carotid femoral pulse wave velocity, fingertip tonometry. | Change from baseline at 2 hours |
| Reactive hyperemia | Change from baseline at 2 hours and 28 days |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Joseph A. Vita, MD | Boston University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Boston University School of Medicine | Boston | Massachusetts | 02118 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 24366423 | Derived | Flint N, Hamburg NM, Holbrook M, Dorsey PG, LeLeiko RM, Berger A, de Cock P, Bosscher D, Vita JA. Effects of erythritol on endothelial function in patients with type 2 diabetes mellitus: a pilot study. Acta Diabetol. 2014;51(3):513-6. doi: 10.1007/s00592-013-0534-2. Epub 2013 Dec 24. |
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| ID | Term |
|---|---|
| D003924 | Diabetes Mellitus, Type 2 |
| D003920 | Diabetes Mellitus |
| ID | Term |
|---|---|
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
| D004700 | Endocrine System Diseases |
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| Carotid femoral pulse wave velocity | Change from baseline at 28 days |
| Fingertip tonometry | Change from baseline at 2 hours and 28 days |
| Urine F2 isoprostanes | Change from baseline at 28 days |
| C-reactive protein | Change from baseline at 28 days |