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| ID | Type | Description | Link |
|---|---|---|---|
| 5P01HL068758-10 | U.S. NIH Grant/Contract | View source |
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| Name | Class |
|---|---|
| National Heart, Lung, and Blood Institute (NHLBI) | NIH |
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The present study is designed to test the hypothesis that resveratrol supplementation will improve the function of the endothelium in patients with type 2 diabetes mellitus.
The function of the endothelium will be tested with a non-invasive technique that uses ultrasound to measure the amount of dilation that occurs in the brachial artery following 5-minute cuff occlusion. To help us understand potential mechanisms of benefit, we will also collect blood, urine, and cell samples and test the effects of treatment on protein expression, nitric oxide production, and function of mitochondria.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Active First | Experimental | Active resveratrol first, placebo second |
|
| Placebo first | Experimental | Placebo first, active resveratrol second |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Resveratrol | Dietary Supplement | Resveratrol 100 mg daily for 2 weeks followed by resveratrol 300 mg daily for 2 weeks. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Change from baseline in Brachial artery flow mediated dilation | 2 hours, 2 weeks, and 4 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Change from Baseline in Fingertip peripheral arterial tonometry | 2 hours, 2 weeks, and 4 weeks | |
| Change from Baseline in Carotid femoral pulse wave velocity | 4 weeks | |
| Measure | Description | Time Frame |
|---|---|---|
| Change from Baseline in Serum glucose | 2 and 4 weeks | |
| Change from Baseline in Serum insulin | 2 and 4 weeks | |
| Change from Baseline in Mononuclear cell mitochondrial DNA damage |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Naomi Hamburg, MD | Boston University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Boston University Medical Center | Boston | Massachusetts | 02118 | United States |
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| ID | Term |
|---|---|
| D003920 | Diabetes Mellitus |
| ID | Term |
|---|---|
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
| D004700 | Endocrine System Diseases |
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| ID | Term |
|---|---|
| D000077185 | Resveratrol |
| ID | Term |
|---|---|
| D000081225 | Stilbestrols |
| D013267 | Stilbenes |
| D001597 | Benzylidene Compounds |
| D001555 | Benzene Derivatives |
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| Placebo | Dietary Supplement | Placebo 100 mg daily for 2 weeks followed by placebo 300 mg daily for 2 weeks. |
|
| Change from Baseline in Reactive hyperemia |
| 2 hours, 2 weeks, 4 weeks |
| 4 weejs |
| Change from Baseline in Mononuclear cell mitochondrial mass | 4 weeks |
| Change from Baseline in Mononuclear cell mitochondrial production of reactive oxygen species | 4 weeks |
| Change from Baseline in Endothelial cell gene expression | 4 weeks |
| Change from Baseline in Endothelial cell protein expression | 4 weeks |
| D006841 |
| Hydrocarbons, Aromatic |
| D006844 | Hydrocarbons, Cyclic |
| D006838 | Hydrocarbons |
| D009930 | Organic Chemicals |
| D059808 | Polyphenols |
| D010636 | Phenols |