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The aim of the present study was to demonstrate the influences of three different treatment strategies on biochemical parameters and testicular volume (TV) in patients with idiopathic hypogonadotropic hypogonadism (IHH).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| hypogonadism, treatment | Other | 77 patients with idiopathic hypogonadotropic hypogonadism were treated with testosterone gel, testosterone enanthate or human chorionic gonadotropin |
|
| Control group | No Intervention | 42 healthy controls |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Testosterone enanthate (Sustanon 250 mg) | Drug | Twenty-eight patients were treated with testosterone enanthate (TE), |
|
| Measure | Description | Time Frame |
|---|---|---|
| Effects of testosterone enanthate and testosterone gel on BMI, haemoglobin, haematocrit, urea creatinine, triglyceride, total testosterone (TT) and HDL-cholesterol were measured. | 3 years | |
| Effects of testosterone gel on BMI, haemoglobin, haematocrit, urea creatinine, triglyceride, total testosterone (TT) and HDL-cholesterol were measured. | 3 years | |
| Effects of human chorionic gonadotrophin on BMI, haemoglobin, haematocrit, urea creatinine, triglyceride, total testosterone (TT) and HDL-cholesterol were measured. | 3 years |
| Measure | Description | Time Frame |
|---|---|---|
| Effect of testosterone enanthate on testis volumes | 3 years | |
| Effect of testosterone gel on testis volumes | 3 years | |
| Effect of human chorionic gonadotrophin on testis volumes |
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Inclusion Criteria: hypogonadotropic hypogonadism
Exclusion Criteria:
Participants with iron, vitamin B12 or folate deficiency were also excluded.
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| Name | Affiliation | Role |
|---|---|---|
| Aydogan Aydogdu, MD | Gulhane School of Medicine, Department of Endocrinology and Metabolism | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Gulhane School of Medicine Dep. of Endocrine and Metabolism | Ankara | 06018 | Turkey (Türkiye) | |||
| Gulhane School of Medicine Dep. of Endocrinology and Metabolism |
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| ID | Term |
|---|---|
| C562785 | Idiopathic Hypogonadotropic Hypogonadism |
| D007006 | Hypogonadism |
| ID | Term |
|---|---|
| D006058 | Gonadal Disorders |
| D004700 | Endocrine System Diseases |
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| ID | Term |
|---|---|
| C004648 | testosterone enanthate |
| D013739 | Testosterone |
| D006063 | Chorionic Gonadotropin |
| ID | Term |
|---|---|
| D000737 | Androstenols |
| D000736 | Androstenes |
| D000731 | Androstanes |
| D013256 | Steroids |
| D000072473 |
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| Human chorionic gonadotropin (hCG) (Pregnyl 5000 IU) | Drug | twenty-five patients were treated with human chorionic gonadotropin (hCG) |
|
| Testosteron gel (Testojel 50 mg) | Drug | Twenty-four patients were treated with testosterone gel (TG). |
|
| 3 years |
| Ankara |
| 06018 |
| Turkey (Türkiye) |
| Fused-Ring Compounds |
| D011083 | Polycyclic Compounds |
| D045165 | Testosterone Congeners |
| D012739 | Gonadal Steroid Hormones |
| D042341 | Gonadal Hormones |
| D006728 | Hormones |
| D006730 | Hormones, Hormone Substitutes, and Hormone Antagonists |
| D006062 | Gonadotropins |
| D036361 | Peptide Hormones |
| D010926 | Placental Hormones |
| D010455 | Peptides |
| D000602 | Amino Acids, Peptides, and Proteins |
| D011257 | Pregnancy Proteins |
| D011506 | Proteins |