Effects of Medications in Patients With Hypogonadism

Effects of Three Different Medications on Metabolic Parameters and Testicular Volume in Patients With Hypogonadotropic Hypogonadism-Last Three Years Experience

The aim of the present study was to demonstrate the influences of three different treatment strategies on biochemical parameters and testicular volume (TV) in patients with idiopathic hypogonadotropic hypogonadism (IHH).

Inclusion Criteria: hypogonadotropic hypogonadism

• decreased serum testosterone concentration below the normal range (serum T < 300ng/dL),
• FSH and LH levels within or below the normal range,
• absence of a pituitary or hypothalamic mass lesions on MRI, presence of gonadotropin response to repetitive doses of GnRH,
• normal smell test and normal karyotypes

Exclusion Criteria:

• previous androgen treatment,
• history of smoking,
• presence of bilateral anorchia,
• intellectual deficiency,
• diabetes mellitus,
• arterial hypertension or dyslipoproteinemia,
• medication of any kind and drug abuse. Because of possible confounding effects, patients with other hormone deficiencies were excluded.

Participants with iron, vitamin B12 or folate deficiency were also excluded.