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The purpose of this study is to investigate the effect of co-administration with erythromycin on the time course of PH-797804 concentration in the blood following dosing by oral immediate release tablet formulation.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| PH-797804 6 mg | Experimental | Subjects will receive a single 6 mg dose in the fed state |
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| PH-797804 6 mg + erythromycin 800 mg | Experimental | Subjects will receive multiple 800 mg doses of erythromycin and a single 6 mg dose of PH-797804 in the fed state |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| PH-797804 | Drug | Tablet, 6mg, single |
| |
| PH-797804 + erythromycin |
| Measure | Description | Time Frame |
|---|---|---|
| Maximum Observed Plasma Concentration (Cmax) | 0,1,2,3,4,6,8,12,24,48,72,96,120,144,168,192,216,240 hours post-dose | |
| Time to Reach Maximum Observed Plasma Concentration (Tmax) | 0,1,2,3,4,6,8,12,24,48,72,96,120,144,168,192,216,240 hours post-dose | |
| Area Under the Curve From Time Zero to Last Quantifiable Concentration (AUClast) | 0,1,2,3,4,6,8,12,24,48,72,96,120,144,168,192,216,240 hours post-dose | |
| Plasma Decay Half-Life (t1/2) | 0,1,2,3,4,6,8,12,24,48,72,96,120,144,168,192,216,240 hours post-dose | |
| Area Under the Curve From Time Zero to Extrapolated Infinite Time [AUC (0 - ∞)] | 0,1,2,3,4,6,8,12,24,48,72,96,120,144,168,192,216,240 hours post-dose |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Pfizer CT.gov Call Center | Pfizer | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Pfizer Investigational Site | Singapore | Singapore | 188770 | Singapore |
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| Label | URL |
|---|---|
| To obtain contact information for a study center near you, click here. | View source |
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| ID | Term |
|---|---|
| C542398 | PH 797804 |
| D004917 | Erythromycin |
| ID | Term |
|---|---|
| D018942 | Macrolides |
| D061065 | Polyketides |
| D007783 | Lactones |
| D009930 | Organic Chemicals |
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| Drug |
PH-797804: tablet, 6mg, single erythromycin: tablet, 400 mg, multiple |
|