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| Name | Class |
|---|---|
| University Hospital, Ioannina | OTHER |
| Catheterization Laboratory of 1st IKA Hospital, Athens | UNKNOWN |
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In the present study the investigators will measure the extent of coronary artery disease via coronary angiography and the correlating risk factors.
In the present study the investigators will examine the risk factors determining the development, extent and the manifestation of coronary artery disease. The study will recruit patients undergoing coronary angiography for clinical purposes.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Diabetes Mellitus | All patients undergoing coronary angiography who are diabetics. | ||
| No diabetes mellitus | All patients undergoing coronary angiography that are non-diabetics. | ||
| Coronary angiography patients | Diabetics and non-diabetics with or without known CV disease who are admitted in the Department of Cardiology in the University Hospital of Ioannina and the Catheterization Laboratory of 1st IKA Hospital in Athens and undergo coronary angiography for clinical purposes will be studied. The study will include subjects who 1) have suspected CAD and undergo a scheduled diagnostic angiogram for clinical reasons, and 2) are hospitalized because of an acute coronary syndrome and thus undergo diagnostic angiography (with or without previous history of CAD). |
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| Measure | Description | Time Frame |
|---|---|---|
| The incidence and extent of coronary artery disease between diabetics and non-diabetic patients. | We will investigate the incidence, extent and clinical manifestation of coronary artery disease in diabetics and non-diabetics undergoing coronary angiography for clinical reasons. | Up to four years on average. |
| Measure | Description | Time Frame |
|---|---|---|
| The incidence and extent of coronary artery disease via coronary angiography scores and related biochemical and demographical risk factors. | To associate the incidence, extent and clinical manifestation of coronary artery disease with classic demographic risk factors (such as smoking, alcohol consumption, physical exercise, arterial hypertension, family history of diabetes mellitus or coronary artery disease) and common biochemical risk factors (such as fasting glucose levels, urea, creatinine, HbA1c%, uric acid, total cholesterol, HDL, LDL, triglycerides, VLDL, glomerular filtration rate - GFR). |
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Inclusion Criteria:
Exclusion Criteria:
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Diabetics and non-diabetics who are admitted in the Cardiology Department in the University Hospital of Ioannina and undergo coronary angiography for clinical purposes will be studied. The study will include subjects who have suspected stable CAD or an acute coronary syndrome and undergo a diagnostic angiography. Patients revascularized in the past (either coronary artery bypass grafting or percutaneous coronary intervention) will be excluded from the study since it is not possible to describe the extent of CAD in these patients.
We plan to recruit about 1,000 patients in about 2 years in order for valid conclusions to be drawn from association analysis between CV risk factors, gene polymorphisms and the presence and extent of CAD.
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| Name | Affiliation | Role |
|---|---|---|
| Katerina Naka, As Professor | University of Ioannina | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| 2nd Department of Cardiology, University Hospital of Ioannina | Ioannina | 45110 | Greece |
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Includes retaining blood samples for DNA analyses and biochemical markers.
| Up to 4 years on average. |
| The incidence, extent and clinical manifestation of coronary artery disease and the circulating levels of hs-CRP, adipokines and RAGEs. | To associate the incidence, extent and clinical manifestation of coronary artery disease with systemic inflammatory status assessed by hs-CRP levels, circulating adipokines (adiponectin, resistin) and the receptors of advanced glycation end products (sRAGE and esRAGE). | Up to 4 years on average. |
| TCF7L2 gene polymorphims and the incidence and extent of coronary artery disease. | To associate the incidence, extent and clinical manifestation of coronary artery disease with the rs7903146 single nucleotide polymorphism of TCF7L2 gene, that has been strongly associated with diabetes mellitus development. | Within a maximum period of 4 years. |