Noninvasive Methods in Diagnosing Coronary Heart Disease in Diabetic Patients

Application in High Risk Groups of Recently Developed Noninvasive Methods in Diagnosing Coronary Heart Disease.A Community Based Study.

The purpose of this study is to investigate the prevalence of cardiac disease/coronary artery disease and diagnostic yield of different non-invasive methods in patients with type 2 diabetes 40-75 years of age at examination. Exercise tests, Doppler echocardiographic examination with Tissue Velocity Imaging, stress Echocardiography, transthoracic Doppler of coronary arteries with coronary flow reserve, and cardiac MRI with late enhancement at rest, and perfusion after vasodilatation stress will be used in the study. A subpopulation will in addition measure forearm vasodilation(FMD) and CFR before and after 4 months of exercise training.

Inclusion Criteria:

• Type 2 diabetes
• Age at diagnosis > 30 years
• Age at inclusion 40-75 years

Exclusion Criteria:

• Angina pectoris
• Coronary angiography/stress-test diagnostic of coronary artery disease last 3 years
• Previous myocardial infarction, coronary bypass operation/PCI or heart failure
• Clinical indication for stress -testing
• Active bronchospasm excluding use of adenosine
• eGFR < 30 ml/min/m2
• short estimated life expectancy due to cancer, chronic liver/renal diseases