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| Name | Class |
|---|---|
| Volda Hospital | OTHER |
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The purpose of this study is to investigate the prevalence of cardiac disease/coronary artery disease and diagnostic yield of different non-invasive methods in patients with type 2 diabetes 40-75 years of age at examination. Exercise tests, Doppler echocardiographic examination with Tissue Velocity Imaging, stress Echocardiography, transthoracic Doppler of coronary arteries with coronary flow reserve, and cardiac MRI with late enhancement at rest, and perfusion after vasodilatation stress will be used in the study. A subpopulation will in addition measure forearm vasodilation(FMD) and CFR before and after 4 months of exercise training.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Type 2 diabetes age 40-75 | Only one diagnostic/observational group |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Diagnostic | Other | Diagnostic non-invasive tests:Dopplerechocardiography, cardiac MRI |
|
| Measure | Description | Time Frame |
|---|---|---|
| Prevalence of cardiac abnormalities/disease according to different examination modalities | at primary examination |
| Measure | Description | Time Frame |
|---|---|---|
| Feasibility of transthoracic coronary Doppler examination/Coronary Flow Reserve, and diagnostic yield related to MRI. | Descriptive study; that is at baseline examination except substudy training group which will also be examined after 4 months of exercise training | at baseline |
| Relationship between CFR in LAD and forearm FMD |
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Inclusion Criteria:
Exclusion Criteria:
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Type 2 diabetes without known cardiac disease between 40 and 75 years of age
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| Name | Affiliation | Role |
|---|---|---|
| Torstein L Hole, MD, PhD | Norwegian University of Science and Technology | Study Chair |
| Rune Wiseth, Md, Phd | Norwegian University of Science and Technology | Study Chair |
| Svein Hareide, MD | Norwegian University of Science and Technology | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Volda Hospital HF | Volda | N-6100 | Norway |
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| ID | Term |
|---|---|
| D003924 | Diabetes Mellitus, Type 2 |
| ID | Term |
|---|---|
| D003920 | Diabetes Mellitus |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
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Routine laboratory tests, parameters to caracterize diabetes controle, inflammatory markers.
Relationship between CFR in LAD and forearm FMD before and after 4 months of exercise training in diabetics. Substudy |
| 4 months |
| Doppler echocardiographic findings related to clinical, laboratory and MRI findings | Special emphasis on new modalities as strain/strain rate at rest and stress. At baseline examination (no follow up) | at baseline |
| Feasibility of transthoracic coronary Doppler examination/Coronary Flow Reserve, and diagnostic yield related to MRI | in exercise training group | 4 months |
| D004700 | Endocrine System Diseases |