The aim of the study is to determine the safety and feasibility of an autologous mononuclear stem cells infusion in pressure ulcers of paraplegic patients; and moreover, to evaluate the efficacy of the treatment.

Taking into account the encouraging results obtained in the treatment of non-healing chronic wounds using bone marrow cells Given that treatment strategies for pressure ulcers can be both costly and complex, in this study we examine the possibility of improving pressure ulcer healing using stem cell therapy.

Inclusion Criteria:

• Type IV ulcer pressures of more than 4 months topical treatment without response
• No option for conventional surgery
• Age range of 18-75 years old

Exclusion Criteria:

• Patients out of inclusion age range
• Patients with evidences of mental illness
• Patients with evidences of previous alcohol or drugs dependencies
• Pregnant women
• Patients with present or previous malignant disease during the last 5 years, except for basal cell carcinoma