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| Name | Class |
|---|---|
| Oswaldo Cruz Foundation | OTHER |
| Irep Sociedade de Ensino Superior Médio e Fundamental Limitada | OTHER |
| Hospital Espanhol | NETWORK |
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This research investigates the use of autologous bone marrow stem cells in patients with spinal cord injury.
The aim of this study is to evaluate autologous bone marrow stem cells transplantation as a safe and potentially beneficial treatment for patients with spinal cord injury.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Stem Cell Transplantation | Experimental | Patients with spinal cord injury that will undergo autologous bone marrow stem cell transplantation. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Stem Cell Transplantation | Procedure | All patients will undergo autologous bone marrow stem cell transplantation into the lesion area. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Feasibility and safety of bone marrow stem cell transplantation in patients with spinal cord injury | Six months |
| Measure | Description | Time Frame |
|---|---|---|
| Functional improvement in muscle strength | Functional improvement in muscle strength assessed by the Frankel scale. | Six months |
| Improvement of sphincters control. | Improvement of sphincters control (anal and bladder). |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Ricardo R. dos Santos, MD, PhD | Hospital Sao Rafael | Principal Investigator |
| Milena Botelho P. Soares, PhD | Hospital Sao Rafael | Study Director |
| Marcus VinÃcius P. Mendonça, MD | Hospital Sao Rafael | Study Chair |
| Cláudia B. Pinheiro, PhD | Hospital Sao Rafael | Study Chair |
| Ticiana X. Ferreira, MD | Hospital Sao Rafael | Study Chair |
| Cristiane F. Villarreal, PhD | Hospital Sao Rafael | Study Chair |
| Luiz Flávio M. Silva, MD | Hospital Sao Rafael | Study Chair |
| Marco A. Almeida, MD | Hospital Sao Rafael | Study Chair |
| Ubirajara B. Júnior, MD, PhD | Hospital Sao Rafael | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hospital São Rafael | Salvador | Estado de Bahia | 41256900 | Brazil |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 25406723 | Derived | Mendonca MV, Larocca TF, de Freitas Souza BS, Villarreal CF, Silva LF, Matos AC, Novaes MA, Bahia CM, de Oliveira Melo Martinez AC, Kaneto CM, Furtado SB, Sampaio GP, Soares MB, dos Santos RR. Safety and neurological assessments after autologous transplantation of bone marrow mesenchymal stem cells in subjects with chronic spinal cord injury. Stem Cell Res Ther. 2014 Nov 17;5(6):126. doi: 10.1186/scrt516. |
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| ID | Term |
|---|---|
| D013119 | Spinal Cord Injuries |
| ID | Term |
|---|---|
| D013118 | Spinal Cord Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
| D020196 | Trauma, Nervous System |
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| ID | Term |
|---|---|
| D033581 | Stem Cell Transplantation |
| ID | Term |
|---|---|
| D017690 | Cell Transplantation |
| D064987 | Cell- and Tissue-Based Therapy |
| D001691 | Biological Therapy |
| D013812 | Therapeutics |
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Mesenchymal stem cell transplantation.
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| Six months |
| D014947 | Wounds and Injuries |
| D014180 |
| Transplantation |
| D013514 | Surgical Procedures, Operative |