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| Name | Class |
|---|---|
| Ontario Ministry of Agriculture, Food and Rural Affairs | OTHER_GOV |
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The hypothesis is that richly coloured purple vegetables, rich in polyphenolic compounds including anthocyanins will have higher antioxidant and other biological activities, than more lightly coloured versions of these foods. Diets of human subjects will be modified to allow consumption of 200-300 g of raw carrots or cooked potatoes. Participants will be randomized to consume either orange or purple carrots, or white or purple potatoes. They will consume these diets for 12 weeks and bioavailability of polyphenolics will be examined as well as anthropometry and blood biochemistry for changes in risk factors associated with cardiovascular disease.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| White potato | Placebo Comparator | Participants will consume 300-500 g of cooked white potatoes per day |
|
| Purple Potato | Experimental | Participants will consume 300-500 g of cooked purple potato per day |
|
| Orange carrots | Placebo Comparator | Participants will consume 200-300 g typical varieties of orange carrots during the intervention |
|
| Purple Carrots | Experimental | Participants will consume 200-300 g raw purple carrots instead of orange carrots in the control arm |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| vegetable | Other | 200-300 g raw carrots or 300-500 g cooked potatoes |
|
| Measure | Description | Time Frame |
|---|---|---|
| Blood cholesterol | blood will be collected at baseline before the experimental foods are introduced and again 6 weeks into the intervention period and during the last week of the intervention (week 12) | 12 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| blood pressure | Participants will have their body weight and blood pressure taken at weekly counselling sessions | 12 weeks |
| body composition | body composition will be measured in well hydrated subjects using bioelectric impedence analysis |
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Inclusion Criteria:
adult men and women 18-65 years of age
must have a least one of the following risk factors associated with increased risk of type II diabetes and/or cardiovascular disease:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Kelly A Meckling, PhD | Contact | 5198244120 | 53742 | kmecklin@uoguelph.ca |
| Saqib Mannan, BSc | Contact | 5198244120 | 53728 | smannan@uoguelph.ca |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Human Nutraceutical Research Unit | Recruiting | Guelph | Ontario | N1G2W1 | Canada |
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| ID | Term |
|---|---|
| D006973 | Hypertension |
| D006937 | Hypercholesterolemia |
| D003924 | Diabetes Mellitus, Type 2 |
| D009765 | Obesity |
| D007249 | Inflammation |
| D007333 | Insulin Resistance |
| D050197 | Atherosclerosis |
| D024821 | Metabolic Syndrome |
| ID | Term |
|---|---|
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
| D006949 | Hyperlipidemias |
| D050171 | Dyslipidemias |
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| ID | Term |
|---|---|
| D014675 | Vegetables |
| ID | Term |
|---|---|
| D005502 | Food |
| D000066888 | Diet, Food, and Nutrition |
| D010829 | Physiological Phenomena |
| D019602 | Food and Beverages |
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| 12 weeks |
| insulin resistance | insulin resistance will be measured by way of an oral glucose tolerance test and collection of venous blood samples for the subsequent 3 hours on two occasions, baseline and during the last week of the intervention diet. | 12 weeks |
| blood and urinary polyphenol metabolites | venous blood and urine will be collected to determine the metabolic profiles of polyphenolics in individual participants. Based on intake data, the bioavailability of the polyphenols in the foods will be estimated. | 12 weeks |
| circulating biomarkers of cardiovascular disease and type II diabetes risk | Blood will be collected for measurement of multiple cytokines, growth factors and other blood biomarkers associated with these diseases. | 12 weeks |
| D052439 |
| Lipid Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
| D003920 | Diabetes Mellitus |
| D044882 | Glucose Metabolism Disorders |
| D004700 | Endocrine System Diseases |
| D050177 | Overweight |
| D044343 | Overnutrition |
| D009748 | Nutrition Disorders |
| D001835 | Body Weight |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D010335 | Pathologic Processes |
| D006946 | Hyperinsulinism |
| D001161 | Arteriosclerosis |
| D001157 | Arterial Occlusive Diseases |