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Endoscopic injection of autologous blood can control bleeding from gastroduodenal ulcers.
To test the hypothesis that endoscopic injection of autologous blood is superior to endoscopic injection of diluted epinephrine in controlling bleeding from gastroduodenal ulcers.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Autologous blood | Active Comparator | Patients will be injected by autologous blood at the edge of actively bleeding ulcer |
|
| Epinephrine injection | Other | Patients will be injected by diluted epinephrine at the edge of actively bleeding ulcer |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Epinephrine | Drug | 10-30 cc of 1/10000 diluted epinephrine will be injected at edges of an actively bleeding ulcer. |
|
| Measure | Description | Time Frame |
|---|---|---|
| hemostasis from the ulcer after injection and/or stoppage of haematemesis and melena one day after the procedure. | 12 months |
| Measure | Description | Time Frame |
|---|---|---|
| development of re-bleeding after 24 hours after the procedure (occurrence of hematemesis or melena or drop of hemoglobin level >2gm/dl). | 12 months |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Mohamed H Emara, MD | Tropical Medicine Department, Faculty of Medicine, Zagazig University, Zagazig, 44519, Egypt | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Zagazig University Hospitals | Zagazig | Sharqia Province | 44519 | Egypt |
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| Label | URL |
|---|---|
| Our Department official journal | View source |
| Our Hospital | View source |
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| Blood | Biological | 5-20 cc autologous blood immediately withdrawn from the patient will be injected at edges of the actively bleeding ulcer. |
|
| ID | Term |
|---|---|
| D014456 | Ulcer |
| ID | Term |
|---|---|
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| ID | Term |
|---|---|
| D004837 | Epinephrine |
| D001800 | Blood Specimen Collection |
| ID | Term |
|---|---|
| D004983 | Ethanolamines |
| D000605 | Amino Alcohols |
| D000438 | Alcohols |
| D009930 | Organic Chemicals |
| D000588 | Amines |
| D015306 | Biogenic Monoamines |
| D001679 | Biogenic Amines |
| D002395 | Catecholamines |
| D002396 | Catechols |
| D010636 | Phenols |
| D001555 | Benzene Derivatives |
| D006841 | Hydrocarbons, Aromatic |
| D006844 | Hydrocarbons, Cyclic |
| D006838 | Hydrocarbons |
| D013048 | Specimen Handling |
| D019411 | Clinical Laboratory Techniques |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
| D011677 | Punctures |
| D013514 | Surgical Procedures, Operative |
| D008919 | Investigative Techniques |
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