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| Name | Class |
|---|---|
| Cato Research | INDUSTRY |
| JSS Medical Research Inc. | INDUSTRY |
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The current study will assess the real - life effectiveness of adalimumab in the management of articular and dermatological manifestations of moderate to severe Psoriatic Arthritis (PsA).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| adalimumab | Responding to treatment with non-biologic DMARDs (disease-modifying antirheumatic drugs) and initiated on treatment with adalimumab as monotherapy or in combination with other medications | ||
| DMARD (disease-modifying antirheumatic drugs) | Initiated on non-biologic DMARD(disease-modifying antirheumatic drugs) or requiring switching to another non biologic DMARD (disease-modifying antirheumatic drugs) as monotherapy, or in combination with other medications |
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| Measure | Description | Time Frame |
|---|---|---|
| Change in the Disease Activity Score - 28 (DAS-28) | The DAS - 28 is calculated using the number of swollen (SJC) and tender (TJC) joints out of 28, the erythrocyte sedimentation rate (ESR) and the patient's global assessment of disease activity using a 100 mm visual analogue scale (VAS) | Every 3 months up to 6 months, then every 6 months up to 24 months |
| Measure | Description | Time Frame |
|---|---|---|
| Duration of Morning Stiffness (min) | This is ascertained by the treating physician during the patient assessment and is measured in minutes | Every 3 months up to 6 months, then every 6 months up to 24 months |
| Dermatology Life Quality Index (DLQI) |
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Inclusion Criteria:
Exclusion Criteria:
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Offices of community rheumatologists & dermatologists
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| Name | Affiliation | Role |
|---|---|---|
| AbbVie Inc. | AbbVie | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Pont, Cranbrook, BC, CA /ID# 69120 | Cranbrook | British Columbia | V1C 2R7 | Canada | ||
| Dr. Barbara T. Blumenauer Inc. /ID# 75393 |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 35033999 | Derived | Khraishi MM, Remple VP, Silverberg S, Stewart JC, Florica B, Bessette L. Canadian Adalimumab Postmarketing Observational Epidemiological Study Assessing Effectiveness in Psoriatic Arthritis (COMPLETE-PsA): 12-month Results of Comparative Effectiveness of Adalimumab and nbDMARDs. J Rheumatol. 2022 May;49(5):454-464. doi: 10.3899/jrheum.200609. Epub 2022 Jan 15. |
| Label | URL |
|---|---|
| Related Info | View source |
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This is a self-administered questionnaire comprised of 10 items assessing a patient's skin and problems associated with skin disease. The 10 questions in the DLQI converge into six domains that measure symptoms and feelings, daily activities, leisure, work and / or school, personal relationships and satisfaction with treatment.
| Baseline, month 6, month12, month 24 |
| Health Assessment Questionnaire - Disability Index (HAQ-DI) | Self-administered questionnaire measuring the patient's functional ability during the last week. | Every 3 months up to 6 months, then every 6 months up to 24 months |
| Patient Global Assessment of Disease Activity (VAS and 5 Point Scale) | A 100 mm VAS with 0 indicating lowest disease and 100 highest disease activity and a five point Likert Scale (0 - 4) that is completed by the patient at the physician's office | Every 3 months up to 6 months, then every 6 months up to 24 months |
| Physician Global Assessment of Disease Activity (VAS and 5 Point Scale) | This is a 100 mm VAS with 0 indicating lowest disease and 100 highest disease activity a five point Likert Scale (0 - 4) that is completed by the physician during the patient examination | Every 3 months up to 6 months, then every 6 months up to 24 months |
| Kamloops |
| British Columbia |
| V2C 0B8 |
| Canada |
| Hudson, Kamloops, Canada /ID# 69104 | Kamloops | British Columbia | V2C 6G6 | Canada |
| Dr. Maqbool R. Sheriff Inc. /ID# 69125 | Nanaimo | British Columbia | V9S 4S1 | Canada |
| Carmi Medical Clinic /ID# 69128 | Penticton | British Columbia | V2A 3G7 | Canada |
| Dr. J. Antonio Avina-Zubieta /ID# 71035 | Richmond | British Columbia | V6X 2C7 | Canada |
| Dr. Alfonso Verdejo Inc. /ID# 69131 | Vancouver | British Columbia | V6Z 2E8 | Canada |
| Dr. Milton F. Baker Inc. /ID# 69085 | Victoria | British Columbia | V8P 5P6 | Canada |
| Manitoba Clinic /ID# 69113 | Winnipeg | Manitoba | R3A IM3 | Canada |
| Nexus Clinical Research /ID# 45622 | St. John's | Newfoundland and Labrador | A1B 5E8 | Canada |
| St. Clare's Mercy Hospital /ID# 69121 | St. John's | Newfoundland and Labrador | A1C 5B8 | Canada |
| Qe Ii Hsc /Id# 69129 | Halifax | Nova Scotia | B3H 1V7 | Canada |
| Dr. Juris Lazovskis Inc. /ID# 69111 | Sydney | Nova Scotia | B1S 3N1 | Canada |
| Waterside Clinique /ID# 72173 | Barrie | Ontario | L4M 6L2 | Canada |
| Shickh, Bowmanville, Canada /ID# 90513 | Bowmanville | Ontario | L1C 1P6 | Canada |
| Brockville Medical Center /ID# 69105 | Brockville | Ontario | K6V 5J9 | Canada |
| Dr. Sanjay Dixit Medicine Professional Corporation /ID# 69092 | Burlington | Ontario | L7L 0B7 | Canada |
| Dr. Chrisotomor Kouroukis & Dr /ID# 137894 | Dundas | Ontario | L9H 1B7 | Canada |
| Charlton Medical Centre /ID# 133073 | Hamilton | Ontario | L8N 1Y2 | Canada |
| Charlton Medical Centre /ID# 69122 | Hamilton | Ontario | L8N 1Y2 | Canada |
| Dr. William G. Bensen Centre /ID# 69086 | Hamilton | Ontario | L8N 1Y2 | Canada |
| West Mountain Medical Center /ID# 128878 | Hamilton | Ontario | L9C 5N2 | Canada |
| Lynderm Research Inc. /ID# 76736 | Markham | Ontario | L3P 1X2 | Canada |
| Brandusa Florica Med Prof Corp /ID# 81876 | Mississauga | Ontario | L5A 3V8 | Canada |
| Credit Valley Rheumatology /ID# 69089 | Mississauga | Ontario | L5M 2V8 | Canada |
| Imtiaz MS Khan Medicine Prof /ID# 69110 | Mississauga | Ontario | L5M 4N4 | Canada |
| Rajwinder S. Dhillon Medicine /ID# 138672 | Niagara Falls | Ontario | L2E 6A6 | Canada |
| Davis, Ottawa, CA /ID# 69091 | Ottawa | Ontario | K2P 1V3 | Canada |
| Setty, Owen Sound, CA /ID# 69123 | Owen Sound | Ontario | N4K 1S4 | Canada |
| York Dermatology Clinic and Research Centre /ID# 127943 | Richmond Hill | Ontario | L4C 9M7 | Canada |
| Pedvis Med Prof Corp /ID# 69388 | Toronto | Ontario | M4S 2C6 | Canada |
| Jonathan Stein Med Prof Corp /ID# 71134 | Toronto | Ontario | M6S 4W4 | Canada |
| Karasik, Toronto, CA /ID# 69109 | Toronto | Ontario | M9C 5N2 | Canada |
| Institut de Rhum. de Montreal /ID# 69100 | Montreal | Quebec | H2L 1S6 | Canada |
| PSS Medical Inc. /ID# 69127 | Montreal | Quebec | H3T 1Y3 | Canada |
| Couture, Outremont, CA /ID# 69090 | Outremont | Quebec | H2V 3Z5 | Canada |
| Ctr. de Rheum de l'est du QC /ID# 69097 | Rimouski | Quebec | G5L 8W1 | Canada |
| Groupe de Recherche en Maladies Osseuses /ID# 69087 | Sainte-Foy | Quebec | G1V 3M7 | Canada |
| CHUS - Hopital Fleurimont /ID# 94735 | Sherbrooke | Quebec | J1H 5N4 | Canada |
| Ctr. de Recherche Musculo-Sque /ID# 69112 | Trois-Rivières | Quebec | G8Z 1Y2 | Canada |
| Rheum Disease Ctr of Montreal /ID# 143964 | Westmount | Quebec | H3Z 2Z3 | Canada |
| ID | Term |
|---|---|
| D015535 | Arthritis, Psoriatic |
| ID | Term |
|---|---|
| D025242 | Spondylarthropathies |
| D025241 | Spondylarthritis |
| D013166 | Spondylitis |
| D013122 | Spinal Diseases |
| D001847 | Bone Diseases |
| D009140 | Musculoskeletal Diseases |
| D001168 | Arthritis |
| D007592 | Joint Diseases |
| D011565 | Psoriasis |
| D017444 | Skin Diseases, Papulosquamous |
| D012871 | Skin Diseases |
| D017437 | Skin and Connective Tissue Diseases |
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