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| Name | Class |
|---|---|
| JSS Medical Research Inc. | INDUSTRY |
| Cato Research | INDUSTRY |
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The current study will assess the real - life effectiveness of adalimumab in the management of Ankylosing Spondylitis (AS) with emphasis on the prevention and management of extra-articular manifestations.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Non-Biologic arm | Patients that have not responded to the current treatment with an NSAID (Nonsteroidal Anti-Inflammatory Drug) and/or non - biologic DMARD (Disease-Modifying Anti Rheumatic Drug) for peripheral joint involvement and switch to or addition of another NSAID /DMARDS | ||
| Biologic arm | Patients that have not responded to the current treatment with non biologic DMARDS (Disease-Modifying Anti Rheumatic Drug) /NSAID (Nonsteroidal Anti-Inflammatory Drug) and switch to or addition of adalimumab |
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| Measure | Description | Time Frame |
|---|---|---|
| Occurrence, flare-up or exacerbation of Extra Articular Manifestations in Uveitis | Baseline will be assessed as follows: Never Present, Positive History (Not present- Complete Remission,Time since remission onset; Present- Assessment of severity using a five point Likert scale (0 = Absent (Clear for Psoriasis); 5 = Most Severe)) Follow-up visits will be assessed as follows:Not present (Never present, Complete remission) Present (New Onset or Recurrence, Assessment of severity using a five point Likert scale (0 = Absent; 5 = Most Severe)) | Every 3 months up to 6 months, then every 6 months up to 24 months |
| Occurrence, flare-up or exacerbation of Extra Articular Manifestations in Psoriasis | Baseline will be assessed as follows: Never Present, Positive History (Not present- Complete Remission,Time since remission onset; Present- Assessment of severity using a five point Likert scale (0 = Absent (Clear for Psoriasis); 5 = Most Severe)) Follow-up visits will be assessed as follows:Not present (Never present, Complete remission) Present (New Onset or Recurrence, Assessment of severity using a five point Likert scale (0 = Absent; 5 = Most Severe)) | Every 3 months up to 6 months, then every 6 months up to 24 months |
| Occurrence, flare-up or exacerbation of Extra Articular Manifestations in Inflammatory Bowel Disease | Baseline will be assessed as follows: Never Present, Positive History (Not present- Complete Remission,Time since remission onset; Present- Assessment of severity using a five point Likert scale (0 = Absent (Clear for Psoriasis); 5 = Most Severe)) Follow-up visits will be assessed as follows:Not present (Never present, Complete remission) Present (New Onset or Recurrence, Assessment of severity using a five point Likert scale (0 = Absent; 5 = Most Severe)) | Every 3 months up to 6 months, then every 6 months up to 24 months |
| Occurrence, flare-up or exacerbation of Extra Articular Manifestations in Enthesitis of the Heel: Achilles Tendon and Plantar Fascia | Baseline will be assessed as follows: Never Present, Positive History (Not present- Complete Remission,Time since remission onset; Present- Assessment of severity using a five point Likert scale (0 = Absent (Clear for Psoriasis); 5 = Most Severe)) Follow-up visits will be assessed as follows:Not present (Never present, Complete remission) Present (New Onset or Recurrence, Assessment of severity using a five point Likert scale (0 = Absent; 5 = Most Severe)) |
| Measure | Description | Time Frame |
|---|---|---|
| BASFI (Bath AS Functional Assay) | This is a 100 VAS with 0 indicating lowest functional limitations and 10 highest functional limitations | Every 3 months up to 6 months, then every 6 months up to 24 months |
| PASQ (Psoriasis and Arthritis Screening Questionnaire) |
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Inclusion Criteria:
Exclusion Criteria:
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Offices of community rheumatologists
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| Name | Affiliation | Role |
|---|---|---|
| AbbVie Inc. | AbbVie | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Rheumatology Clinic /ID# 54768 | Calgary | Alberta | T2P 0V2 | Canada | ||
| Associate Clinic /ID# 64274 |
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| Label | URL |
|---|---|
| clinical study report synopsis | View source |
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| Every 3 months up to 6 months, then every 6 months up to 24 months |
This is an 11 item tool that ascertains self reported presence of joint pain and swelling. |
| Every 3 months up to 6 months, then every 6 months up to 24 months |
| BASDAI (Bath AS Disease Activity Index) | This is a 100 VAS with 0 indicating lowest disease activity and 10 highest disease activity | Every 3 months up to 6 months, then every 6 months up to 24 months |
| Calgary |
| Alberta |
| T2P 3C5 |
| Canada |
| Pont, Cranbrook, BC, CA /ID# 55242 | Cranbrook | British Columbia | V1C 2R7 | Canada |
| Dr. Barbara T. Blumenauer Inc. /ID# 55226 | Kamloops | British Columbia | V2C 0B8 | Canada |
| Hudson, Kamloops, Canada /ID# 54577 | Kamloops | British Columbia | V2C 6G6 | Canada |
| Dr. Maqbool R. Sheriff Inc. /ID# 55247 | Nanaimo | British Columbia | V9S 4S1 | Canada |
| Stewart, Penticton, CA /ID# 67096 | Penticton | British Columbia | V2A 3G7 | Canada |
| Dr. Michael Buchanan, Inc. /ID# 55227 | Prince George | British Columbia | V2L 5R6 | Canada |
| Dr. J. Antonio Avina-Zubieta /ID# 68263 | Richmond | British Columbia | V6X 2C7 | Canada |
| Dr. Alfonso Verdejo Inc. /ID# 54572 | Vancouver | British Columbia | V6Z 2E8 | Canada |
| Dr. Milton F. Baker Inc. /ID# 55197 | Victoria | British Columbia | V8P 5P6 | Canada |
| Manitoba Clinic /ID# 54580 | Winnipeg | Manitoba | R3A IM3 | Canada |
| Bulleid Henderson Prof. Corp. /ID# 55256 | Fredericton | New Brunswick | E3B 6H5 | Canada |
| Ecker, Fredericton, CA /ID# 54748 | Fredericton | New Brunswick | E3B 6H5 | Canada |
| Nexus Clinical Research /ID# 54757 | St. John's | Newfoundland and Labrador | A1B 5E8 | Canada |
| St. Clare's Mercy Hospital /ID# 54767 | St. John's | Newfoundland and Labrador | A1C 5B8 | Canada |
| Qe Ii Hsc /Id# 55261 | Halifax | Nova Scotia | B3H 1V7 | Canada |
| Dr. Juris Lazovskis Inc. /ID# 61562 | Sydney | Nova Scotia | B1S 3N1 | Canada |
| Pavlova, Hamilton, CA /ID# 65011 | Ancaster | Ontario | L9G 3K9 | Canada |
| Waterside Clinique /ID# 72174 | Barrie | Ontario | L4M 6L2 | Canada |
| Joshi, Brampton, Canada /ID# 54758 | Brampton | Ontario | L6T 3J1 | Canada |
| Brockville Medical Center /ID# 65502 | Brockville | Ontario | K6V 5J9 | Canada |
| Dr. Sanjay Dixit Medicine Professional Corporation /ID# 67347 | Burlington | Ontario | L7L 0B7 | Canada |
| Aviva Clinical Trial Group /ID# 54764 | Burlington | Ontario | L7R 1E2 | Canada |
| Dr. Chrisotomor Kouroukis & Dr /ID# 137831 | Dundas | Ontario | L9H 1B7 | Canada |
| Charlton Medical Centre /ID# 133072 | Hamilton | Ontario | L8N 1Y2 | Canada |
| Charlton Medical Centre /ID# 55417 | Hamilton | Ontario | L8N 1Y2 | Canada |
| Dr. William G. Bensen Centre /ID# 54762 | Hamilton | Ontario | L8N 1Y2 | Canada |
| West Mountain Medical Center /ID# 128877 | Hamilton | Ontario | L9C 5N2 | Canada |
| KW Musculoskeletal Research /ID# 70093 | Kitchener | Ontario | N2M 5N6 | Canada |
| Brandusa Florica Med Prof Corp /ID# 81877 | Mississauga | Ontario | L5A 3V8 | Canada |
| Montgomery, Mississauga, CA /ID# 54581 | Mississauga | Ontario | L5A 3V8 | Canada |
| Credit Valley Rheumatology /ID# 54750 | Mississauga | Ontario | L5M 2V8 | Canada |
| Imtiaz MS Khan Medicine Prof /ID# 55401 | Mississauga | Ontario | L5M 4N4 | Canada |
| Morassut, Nepean, Canada /ID# 55410 | Nepean | Ontario | K2G 6E2 | Canada |
| The Arthritis Program Res Grp /ID# 54755 | Newmarket | Ontario | L3Y 3R7 | Canada |
| Rajwinder S. Dhillon Medicine /ID# 138671 | Niagara Falls | Ontario | L2E 6A6 | Canada |
| Kapur, Ottawa, Canada /ID# 55397 | Ottawa | Ontario | K2A 3Z3 | Canada |
| Davis, Ottawa, CA /ID# 55296 | Ottawa | Ontario | K2P 1V3 | Canada |
| Setty, Owen Sound, CA /ID# 54583 | Owen Sound | Ontario | N4K 1S4 | Canada |
| Niagara Peninsula Arthritis Ct /ID# 67282 | St. Catharines | Ontario | L2N 7E4 | Canada |
| Pedvis Med Prof Corp /ID# 55411 | Toronto | Ontario | M4S 2C6 | Canada |
| Hamilton, Toronto, CA /ID# 54575 | Toronto | Ontario | M4X 1W4 | Canada |
| Jonathan Stein Med Prof Corp /ID# 55451 | Toronto | Ontario | M6S 4W4 | Canada |
| Karasik, Toronto, CA /ID# 54751 | Toronto | Ontario | M9C 5N2 | Canada |
| Dr. Samuel K Silverberg /ID# 55449 | Toronto | Ontario | M9V 4B8 | Canada |
| Ctr de Med Sportive de Laval /ID# 54576 | Laval | Quebec | H7T 2Z8 | Canada |
| Institut de Rhum. de Montreal /ID# 54761 | Montreal | Quebec | H2L 1S6 | Canada |
| Jewish General Hospital /ID# 63655 | Montreal | Quebec | H3T 1E2 | Canada |
| PSS Medical Inc. /ID# 54754 | Montreal | Quebec | H3T 1Y3 | Canada |
| Couture, Outremont, CA /ID# 54574 | Outremont | Quebec | H2V 3Z5 | Canada |
| Ctr. de Rheum de l'est du QC /ID# 54765 | Rimouski | Quebec | G5L 8W1 | Canada |
| Clinique Medicale Langelier /ID# 55460 | Saint-Léonard | Quebec | H1S 3A9 | Canada |
| Groupe de Recherche en Maladies Osseuses /ID# 45623 | Sainte-Foy | Quebec | G1V 3M7 | Canada |
| Ctr. de Recherche Musculo-Sque /ID# 55469 | Trois-Rivières | Quebec | G8Z 1Y2 | Canada |
| Rheum Disease Ctr of Montreal /ID# 143963 | Westmount | Quebec | H3Z 2Z3 | Canada |
| ID | Term |
|---|---|
| D013167 | Spondylitis, Ankylosing |
| ID | Term |
|---|---|
| D000089183 | Axial Spondyloarthritis |
| D025242 | Spondylarthropathies |
| D025241 | Spondylarthritis |
| D013166 | Spondylitis |
| D013122 | Spinal Diseases |
| D001847 | Bone Diseases |
| D009140 | Musculoskeletal Diseases |
| D000844 | Ankylosis |
| D007592 | Joint Diseases |
| D001168 | Arthritis |
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