Effects of Short-term Atorvastatin Treatment on Vaccination Efficacy in Nonresponder Persons to Hepatitis B Vaccine

Effects of Short-term Atorvastatin Treatment on Vaccination Efficacy in Nonresponder Persons to Hepatitis B Vaccine

The purpose of this study is to determine whether short-term Atorvastatin can increase the immunity response to hepatitis B vaccination in vaccine Nonresponders.

20 person of vaccinated individuals who have HBsAb<10 after 3 dose hepatitis B vaccination who called Nonresponders will be randomly allocated in 2 groups. one group receive short-term Atorvastatin and other group receive placebo.both group will be vaccinated with hepatitis B vaccine and then immunity response will be measured.

Inclusion Criteria:

• Previous 3 dose hepatitis B vaccination
• Negative HBc Ab
• Negative HBs Ag
• HBs Ab less than 10 in ELIZA

Exclusion Criteria:

• positive serologic evidence of Hepatitis B infection
• Chronic use of Atorvastatin
• Immunosuppressive Disease