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Upper endoscopy is uncomfortable for most patients. Meperidine has both sedative and analgesic effects, so its use may be helpful for patients receiving upper endoscopy.
Unsedated esophagogastroduodenoscopy (EGD) is a useful tool for upper gastrointestinal tract examination and therapy, but it is uncomfortable for many patients. Meperidine has been widely used in colonoscopic examination for many years; however, its use in EGD has not been completely evaluated.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| meperidine | Experimental | 25 mg of meperidine is injected intramuscularly before EGD |
|
| placebo | Placebo Comparator | placebo was given intramuscularly before EGD |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Meperidine | Drug | intramuscular, 25 mg, 5 to 10 minutes before EGD |
| |
| Measure | Description | Time Frame |
|---|---|---|
| discomfort score during esophageal intubation | patient self-reported discomfort score during esophageal intubation, assessed with a 0 to 10 visual analog scale (VAS) | 9 months |
| Measure | Description | Time Frame |
|---|---|---|
| patient and endoscopist satisfaction score | patient and endoscopist satisfaction with the procedure, score 0(not satisfied at all)-10 (very satisfied | 9 months |
| patient tolerance of the procedure |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Yu-Hsi Hsieh, Dr. | Dalin Tzu Chi General Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Dalin Tzu Chi General Hospital | Chiayi City | Taiwan | 622 | Taiwan |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 15330904 | Background | Abraham NS, Fallone CA, Mayrand S, Huang J, Wieczorek P, Barkun AN. Sedation versus no sedation in the performance of diagnostic upper gastrointestinal endoscopy: a Canadian randomized controlled cost-outcome study. Am J Gastroenterol. 2004 Sep;99(9):1692-9. doi: 10.1111/j.1572-0241.2004.40157.x. | |
| 1473671 | Background |
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| Type | Date | Date Unknown |
|---|---|---|
| Release | Apr 2, 2012 | |
| Reset | Apr 25, 2012 |
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| Release Date | Unrelease Date | Unrelease Date Unknown | Reset Date | MCP Release Number |
|---|---|---|---|---|
| Apr 2, 2012 | Apr 25, 2012 |
| ID | Term |
|---|---|
| D008614 | Meperidine |
| D000077330 | Saline Solution |
| ID | Term |
|---|---|
| D007540 | Isonipecotic Acids |
| D000147 | Acids, Heterocyclic |
| D006571 | Heterocyclic Compounds |
| D010880 | Piperidines |
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| normal saline |
| Drug |
25 ml of normal saline, intramuscular, 5 to 10 minutes before EGD |
|
patolerace of the EGD, evaluate by the endoscopist, score 0 (best tolerance)-10 (very poor tolerance, the procedure could not be completed)
| 9 months |
| endoscopist perception of patient tolerance , | endoscopist evaluation of patient tolerance during EGD, score 0 (best tolerance)- 10 (worst tolerance, the procedure can not be completed) | 9 months |
| Ishido S, Kinoshita Y, Kitajima N, Itoh T, Nishiyama K, Tojo M, Yano T, Inatome T, Fukuzaki H, Chiba T. Fentanyl for sedation during upper gastrointestinal endoscopy. Gastrointest Endosc. 1992 Nov-Dec;38(6):689-92. doi: 10.1016/s0016-5107(92)70565-3. |
| 11231385 | Background | Laluna L, Allen ML, Dimarino AJ Jr. The comparison of midazolam and topical lidocaine spray versus the combination of midazolam, meperidine, and topical lidocaine spray to sedate patients for upper endoscopy. Gastrointest Endosc. 2001 Mar;53(3):289-93. doi: 10.1016/s0016-5107(01)70400-2. |
| 8651156 | Background | Diab FH, King PD, Barthel JS, Marshall JB. Efficacy and safety of combined meperidine and midazolam for EGD sedation compared with midazolam alone. Am J Gastroenterol. 1996 Jun;91(6):1120-5. |
| 23431993 | Derived | Hsieh YH, Lin HJ, Hsieh JJ, Tseng KC, Tseng CW, Hung TH, Leung FW. Meperidine as the single sedative agent during esophagogastroduodenoscopy, a double-blind, randomized, controlled study. J Gastroenterol Hepatol. 2013 Jul;28(7):1167-73. doi: 10.1111/jgh.12183. |
| D006573 |
| Heterocyclic Compounds, 1-Ring |
| D000077324 | Crystalloid Solutions |
| D007552 | Isotonic Solutions |
| D012996 | Solutions |
| D004364 | Pharmaceutical Preparations |