Efficacy and Safety Profiles of Combination Sedation Propofol With Midazolam and Meperidine.

Efficacy and Safety Profiles of Sedation With Propofol Combined With Intravenous Midazolam and Meperidine Versus Intravenous Midazolam and Meperidine for Ambulatory Endoscopic Retrograde-cholangiopancreatography(ERCP).

The purpose of this study is to compare efficacy and safety of combination of propofol and midazolam with meperidine versus midazolam and meperidine for ambulatory ERCP

ERCP is commonly done under sedation with midazolam and meperidine, however some studies showed varying outcomes of this conventional sedation for maintained sedation. Propofol is increasing used for sedation in gastrointestinal procedure owing to its rapid recovery profiles but the complications associated with propofol are not negligible.The investigators prospectively compare the efficacy, induction time, recovery time, patient satisfaction and side effect between propofol based and conventional sedations in patients undergoing ERCP.

Inclusion Criteria:

. All outpatients aged more than 18 years who were schedule for ERCP -

Exclusion Criteria:

• pregnant woman
• emergency situation ( i.e. concomitant upper gastrointestinal bleeding, acute cholangitis )
• American Society of Anesthesiologist ( ASA )Class IV or V
• respiratory disease,
• sleep apnea
• allergy to egg or soybean
• drug abuse( benzodiazepine, opioid agonist )
• previous history of failure sedation