Tacrolimus Ointment in Oral Lichen Planus

Comparison of Topical Tacrolimus, Triamcinolone and Placebo in the Treatment of Symptomatic Oral Lichen Planus

The purpose of this study is to compare the effectiveness of topical tacrolimus, triamcinolone and placebo in alleviating signs and symptoms of oral lichen planus (OLP).

Inclusion Criteria:

• Diagnosis of OLP made by a specialist in oral pathology based on clinical and histopathological features
• Clinical score for OLP ≥ 20 at baseline
• Symptomatic OLP at baseline
• Washout period of 2 weeks
• Age over 18

Exclusion Criteria:

• Pregnant or lactating women
• Allergy to tacrolimus or other macrolides
• Allergy to other drugs or substances used in the study
• Abnormal liver function
• Netherton's syndrome
• Cyclosporin medication
• Other regular medication that could have significant interactions with tacrolimus