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| Name | Class |
|---|---|
| Kuopio University Hospital | OTHER |
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The purpose of this study is to compare the effectiveness of topical tacrolimus, triamcinolone and placebo in alleviating signs and symptoms of oral lichen planus (OLP).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Tacrolimus | Active Comparator | Tacrolimus ointment 0.1%, three times a day for 6-9 weeks. |
|
| Triamcinolone | Active Comparator | Triamcinolone paste 0.1%, three times a day for 3-6 weeks. |
|
| Placebo | Placebo Comparator | Orabase paste, three times a day for 3-6 weeks. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| 0.1 % tacrolimus ointment | Drug | applied topically to oral mucosa |
|
| Measure | Description | Time Frame |
|---|---|---|
| Change in clinical score for OLP | The clinical score for OLP is a measure designed by the investigators for assessing the clinical extent and type of OLP, and the symptoms experienced by the patient. The value of the score is between 0-120. | 1,2,3,4,5,6,7,8 and 9 weeks, 6 months |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Tuula Salo, DDS, PhD | Department of Diagnostics and Oral Medicine, Institute of Dentistry, University of Oulu, Oulu, Finland | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Oral and Maxillofacial Diseases Clinic, Kuopio University Hospital | Kuopio | 70029 | Finland | |||
| Department of Diagnostics and Oral Medicine, Institute of Dentistry, University of Oulu |
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| ID | Term |
|---|---|
| D017676 | Lichen Planus, Oral |
| ID | Term |
|---|---|
| D009059 | Mouth Diseases |
| D009057 | Stomatognathic Diseases |
| D008010 | Lichen Planus |
| D017512 | Lichenoid Eruptions |
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| ID | Term |
|---|---|
| D016559 | Tacrolimus |
| ID | Term |
|---|---|
| D018942 | Macrolides |
| D007783 | Lactones |
| D009930 | Organic Chemicals |
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| 0.1 % triamcinolone paste | Drug | applied topically to oral mucosa |
|
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| Orabase paste | Drug | applied topically to oral mucosa |
|
| Oulu |
| 90014 |
| Finland |
| D017444 |
| Skin Diseases, Papulosquamous |
| D012871 | Skin Diseases |
| D017437 | Skin and Connective Tissue Diseases |