Comparison of Tacrolimus 0.1% and Clobetasol 0.05% in the Management of Symptomatic Oral Lichen Planus

Comparison of Tacrolimus 0.1% and Clobetasol 0.05% in the Management of Symptomatic Oral Lichen Planus- A Double-blinded Randomized Clinical Trial in Sri Lanka

This clinical study is carried out to assess the efficacy of Tacrolimus and Clobetasol in symptomatic Oral Lichen Planus.

Inclusion Criteria:

• Clinically and Histologically proven Oral Lichen Planus
• Symptomatic

Exclusion Criteria:

• topical/ systemic medication for OLP in the previous three months
• contraindication for medications use such as a history of allergy to either corticosteroids/ tacrolimus
• immunosuppression, or pregnant / lactating females
• lichenoid reactions either drug induced or due to dental amalgam
• diabetes mellitus and on oral hypoglycemic drugs
• systemic involvement such as concurrent skin/genital lesions