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intraperitoneal nebulisation with magnesuim sulphate will reduce post operative pain and analgesic consumption in postoperative period following laparoscopic cholecystectomy.
Sixty patients undergoing laparoscopic cholecystectomy belonging to American Society of Anaesthesiologist (I-II) of age 18-65 yrs will be enrolled.Group one (n=30) will receive 1.5 gm magnesium sulphate diluted in 3ml of normal saline and group 2 (n=30) will receive 5 ml of NS.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Magnesium sulphate | Active Comparator | intraperitoneal nebulisation of 1.5 gm of magnesium sulphate with 2 ml of normal saline at the end of surgery before closure |
|
| normal saline | Placebo Comparator | intraperitoneal nebulisation of 5 ml of normal saline after end of surgery before closure |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| intraperitoneal nebulisation of magnesium sulphate | Drug | intraperitoneal nebulisation of 1.5 gm of magnesium sulphate with 2 ml of normal saline |
|
| Measure | Description | Time Frame |
|---|---|---|
| number of analgesic request | time to first analgesic request is taken as duration of effective analgesia number of analgesic request in first 24 hours were also counted | 24 hour |
| Measure | Description | Time Frame |
|---|---|---|
| VAS score | Visual analogue scale is a linear 10cm scale with 0 corresponding to no pain and 10 to worst pain ever | first complaint of pain, 6 hrs, 12 hrs, 24 hrs |
| nausea and vomiting | 24 hrs |
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Inclusion Criteria: ASA I-II
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Exclusion Criteria: history of
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Sujata Niroula, MD | Contact | 00977-9842108624 | drsujataniroula@gmail.com | |
| krishna Pokharel, MD | Contact | 00977-9841986321 | drkrishnapokharel@gmail.com |
| Name | Affiliation | Role |
|---|---|---|
| krishna Pokharel, MD | B.P. Koirala Institute of Health Sciences | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| routine operation theatre of BPKoirala | Recruiting | Dharān | 00977 | Nepal |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 17180268 | Background | Alkhamesi NA, Peck DH, Lomax D, Darzi AW. Intraperitoneal aerosolization of bupivacaine reduces postoperative pain in laparoscopic surgery: a randomized prospective controlled double-blinded clinical trial. Surg Endosc. 2007 Apr;21(4):602-6. doi: 10.1007/s00464-006-9087-6. Epub 2006 Dec 16. | |
| Background | Abdel - Raouf M, Amer H. Postoperative analgesic effects of intraperitoneal NMDA receptor antagonist (ketamine and magnesium sulphate )in patients undergoing laparoscopic cholecystectomy .Eg J Anaesth. 2004;20: 107-11 |
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| ID | Term |
|---|---|
| D010149 | Pain, Postoperative |
| ID | Term |
|---|---|
| D011183 | Postoperative Complications |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D010146 | Pain |
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| respiratory rate | 24 hrs |
| sedation | 24hrs |
| D009461 | Neurologic Manifestations |
| D012816 | Signs and Symptoms |