Efficacy and Safety of Shinbaro Capsule

A 12 Weeks, Randomized, Double-blind, Multi-centers, Phase III Study to Evaluate the Efficacy and Safety of Shinbaro Capsule Compared With Celebrex Capsule in Patients With Osteoarthritis of Knee

The purpose of this study is to evaluate the efficacy and safety of 'Shinbaro Capsule', a new herbal anti-arthritic agent, in patients with osteoarthritis of the knee.

Inclusion Criteria:

• age between 35 and 80
• diagnosed with Knee OA based on criteria of ACR and showed ont through I ~ III of Kellgren Stage on radiography
• wuffered constantly with Knee OA for more than 6 months prior to begining the study
• scored more than 30 on total WOMAC scale

Exclusion Criteria:

• had other comorbid orthopedic disease
• had OA of index knee from significant trauma or surgery