The purpose of this study is to evaluate efficacy and safety of Celecoxib capsule in hand osteoarthritis patients.

This is a six-weeks, open-label, multi-center, randomized study. Patients take Celecoxib 200mg capsule once a day or Celecoxib 100mg capsules twice per day. If patients do not tolerate the pain, they are able to take Acetaminophen as a rescue medication during 6 weeks.

Inclusion Criteria:

• Agreement with written informed consent and 19 years of age and older
• Patients history of OA of hand according to ACR criteria
• The 100mm Pain VAS is over 40mm

Exclusion Criteria:

• History of OA of hand surgery

• Intra-articular injections within 3 months

• History of OA of hand infections within 3 months

• Who had taken a drug that has a control of result in clinical trial by investigator's decision

• Pregnant women, nursing mothers or Fertile women who not practice contraception with appropriate methods

• clinically significant hepatic, renal, cardiovascular diseases

• Any history of adverse reaction to the study drugs

• Patients with gastrointestinal ulcers or bleeding disorders

• Finger joint injury within 6 months

• Who had following results after examination

  1. K ≥ 5.5mEq/L
  2. eGFR ≤ 30ml/min/1.73m^2

• Patients on any other clinical trial or experimental treatment in the past 3 months

• Taking narcotic analgesics or patches

• History of drug abuse or alcoholism

• Who has Galactose intolerance, LAPP lactose intolerance, glucose-galactose malabsorption or genetic disorders

• An impossible one who participates in clinical trial by investigator's decision